NDLI: PRSS1 intron mutations in patients with pancreatic cancer and chronic pancreatitis.

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PRSS1 intron mutations in patients with pancreatic cancer and chronic pancreatitis.

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PRSS1 intron mutations in patients with pancreatic cancer and chronic pancreatitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Sheng Liu, Qi-Cai Lin, Xin-Hua Gao, Feng Zhuang, Ze-Hao Lin, Cai-Zhu
Description	Author Affiliation: Gao F ( Department of Pathology, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, PR China.)
Abstract	Genetic risk factors of chronic pancreatitis (CP) have been identified and a number of studies have found that CP can lead to pancreatic cancer. Therefore, the detection of pancreatitis-associated gene mutations can aid the pancreatic cancer diagnostic process. Mutations in three genes, the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene and the pancreatic secretory trypsin inhibitor (SPINK1) gene, have been identified as risk factors for CP. The aim of this study was to describe specific novel mutations in the intron of the PRSS1 gene in patients with pancreatic cancer and CP. A total of 65 unrelated patients with pancreatic cancer and 29 with CP were reviewed. Mutations and polymorphisms of the PRSS1 gene were analyzed by direct sequencing. Information regarding clinical data and smoking exposure was collected by personal interviews using a structured questionnaire. IVS 3+36 A>G mutation in the PRSS1 gene was found in 2 cases with pancreatic cancer, and these 2 patients were classified as never-smokers. IVS 3+127 T>A and IVS 3+157 G>C double mutations were identified in one patient with CP. All patients were found to have serum trypsin levels lower than that of the normal controls. Therefore, the PRSS1 gene mutation may be a special common cause of pancreatic cancer and CP.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	5
Language	English
Publisher	Spandidos Publications
Publisher Date	2012-02-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Mutation Pancreatic Neoplasms Genetics Pancreatitis, Chronic Trypsin Cohort Studies Introns Polymorphism, Single Nucleotide Retrospective Studies Sequence Analysis, Dna Smoking Blood Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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