NDLI: Opposite effects of cefoperazone and ceftazidime on Sribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate.

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Opposite effects of cefoperazone and ceftazidime on Sribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yong, Xiao-Lan Chen, Jian-Hong Sun, Feng-Jun Ou, Qian-Yi Shi, Hui-Qing Feng, Wei Xia, Pei-Yuan
Description	Author Affiliation: Shi HQ ( Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China.); Sun FJ ( Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China.); Chen JH ( Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China.); Yong XL ( Department of Clinical Pharmacy, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.); Ou QY ( Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China.); Feng W ( Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China.); Xia PY ( Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China.)
Abstract	To investigate the effects of subminimum inhibitory concentrations of cephalosporins on bacterial biofilm formation, the biofilm production of 52 Escherichia (E.) coli strains was examined following treatment with cephalosporin compounds at 1/4 minimum inhibitory concentrations (MICs). Ceftazidime (CAZ) inhibited biofilm formation in seven isolates, while cefoperazone (CFP) enhanced biofilm formation in 18 isolates. Biofilm formation of E. coli E42 was inhibited by CAZ and induced by CFP. Therefore, using reverse transcriptionpolymerase chain reaction, the expression of the biofilmmodulating genes of this isolate was investigated. To monitor the production of the autoinducer of quorum sensing in E. coli, autoinducer2 (AI2) production was detected by measuring the bioluminescence response of Vibrio harveyi BB170. Antisense oligonucleotides (ASODNs) targeting Sribosylhomocysteine lyase (luxS) inhibited the expression of the luxS gene in E. coli. CAZ at 1/4 MIC reduced luxS mRNA levels and the production of AI2, whereas CFP at 1/4 MIC had the opposite effect. ASODNs targeting luxS significantly decreased the aforementioned inhibitory effects of CAZ and the induction effects of CFP on E. coli biofilm formation. Therefore, biofilm formation by the E. coli clinical isolate E42 was evoked by CFP but attenuated by CAZ at subMICs, via a luxS/AI2based quorum sensing system.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2014.2540
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	10
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-11-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Anti-bacterial Agents Pharmacology Bacterial Proteins Metabolism Biofilms Drug Effects Carbon-sulfur Lyases Cefoperazone Ceftazidime Escherichia Coli Proteins Escherichia Coli Physiology Genetics Isolation & Purification Escherichia Coli Infections Microbiology Gene Expression Gene Expression Regulation, Bacterial Genes, Bacterial Microbial Sensitivity Tests Quorum Sensing Rna, Messenger Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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Opposite effects of cefoperazone and ceftazidime on S-ribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate

Establishing bacterial communities by 'word of mouth': LuxS and autoinducer 2 in biofilm development.

Quorum-sensing gene luxS regulates flagella expression and Shiga-like toxin production in F18ab Escherichia coli.

Riemerella anatipestifer lacks luxS, but can uptake exogenous autoinducer-2 to regulate biofilm formation.

Quorum sensing and multidrug transporters in Escherichia coli.

Boron Derivatives Accelerate Biofilm Formation of Recombinant Escherichia coli via Increasing Quorum Sensing System Autoinducer-2 Activity

Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production.

MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli.

Dual function of the McaS small RNA in controlling biofilm formation.

Opposite effects of cefoperazone and ceftazidime on Sribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate.

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Opposite effects of cefoperazone and ceftazidime on S-ribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate

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Opposite effects of cefoperazone and ceftazidime on S­ribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate.

Opposite effects of cefoperazone and ceftazidime on Sribosylhomocysteine lyase/autoinducer-2 quorum sensing and biofilm formation by an Escherichia coli clinical isolate.