NDLI: Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin-resistant ovarian cancer

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Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin-resistant ovarian cancer

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Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin-resistant ovarian cancer

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peng, Zheng Guo, Hongjun Ji, Mei Shi, Huirong Xie, Ya Shi, Mingxing
Description	Author Affiliation: Xie Y ( Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Peng Z ( Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Shi M ( Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Ji M ( Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Guo H ( Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Shi H ( Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.)
Abstract	The aim of the present study was to determine the effects of metformin, combined with a p38 mitogenactivated protein kinase (MAPK) inhibitor, on the sensitivity of cisplatinresistant ovarian cancer to cisplatin. The expression and distribution of phosphorylated p38 MAPK (Pp38 MAPK) was confirmed in drugresistant and primary ovarian cancer tissues by immunohistochemistry and western blotting. A bromodeoxyuridine ELISA kit was used to analyze the effects of metformin, SB203580, a p38 MAPK inhibitor, and metformin combined with SB203580, on the cell proliferation of SKOV3/DDP cisplatinresistant ovarian cancer cells. The protein expression of Pp38 MAPK was significantly higher in cisplatinresistant ovarian cancer, as compared with the primary ovarian cancer tissues. Metformin combined with SB203580 significantly enhanced the sensitivity of SKOV3/DDP cells to cisplatin. In conclusion, the p38 MAPK signaling pathway may be associated with cisplatinresistant ovarian cancer. Metformin, combined with the p38 MAPK inhibitor, significantly increased the sensitivity of SKOV3/DDP cells to cisplatin treatment.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2014.2490
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	10
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-11-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Antineoplastic Agents Pharmacology Cisplatin Imidazoles Metformin Neoplasms, Glandular And Epithelial Drug Therapy Ovarian Neoplasms Pyridines P38 Mitogen-activated Protein Kinases Antagonists & Inhibitors Cell Line, Tumor Cell Proliferation Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Drug Synergism Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin-resistant ovarian cancer

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Tubeimoside I sensitizes cisplatin in cisplatin-resistant human ovarian cancer cells (A2780/DDP) through down-regulation of ERK and up-regulation of p38 signaling pathways.

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