NDLI: Effects of antiviral therapy on the cellular immune response in patients with chronic hepatitis B.

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Expression of hepatocyte growth factor in breast cancer and its effect on prognosis and sensitivity to chemotherapy.

Promoter methylated microRNAs: potential therapeutic targets in gastric cancer.

Determining the neuroprotective effects of dextromethorphan in lipopolysaccharidestimulated BV2 microglia.

Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells.

Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma.

Visfatin: an adipokine activator of rat hepatic stellate cells.

Downregulation of microRNA-429 inhibits cell proliferation by targeting p27Kip1 in human prostate cancer cells.

Activation of S1P2 receptor, a possible mechanism of inhibition of adipogenic differentiation by sphingosine 1phosphate.

Novel IL-6-secreting Î³Î´T cells increased in patients with atherosclerotic cerebral infarction.

Synergic effect between 5fluorouracil and celecoxib on hypoxic gastric cancer cells.

Estrogen receptor ß agonist enhances temozolomide sensitivity of glioma cells by inhibiting PI3K/AKT/mTOR pathway.

Biological characteristics of Taxolresistant ovarian cancer cells and reversal of Taxol resistance by adenovirus expressing p53.

Combination of IGF1 gene manipulation and 5AZA treatment promotes differentiation of mesenchymal stem cells into cardiomyocytelike cells.

Role of cysteinerich angiogenic inducer 61 in fibroblastlike synovial cell proliferation and invasion in rheumatoid arthritis.

GRIM19mediated Stat3 activation is a determinant for resveratrolinduced proliferation and cytotoxicity in cervical tumorderived cell lines.

Vset and transmembrane domaincontaining 1 is silenced in human hematopoietic malignancy cell lines with promoter methylation and has inhibitory effects on cell growth.

Lycopene protects against apoptosis in hypoxia/reoxygenationinduced H9C2 myocardioblast cells through increased autophagy.

Coculture with human fetal epidermal keratinocytes promotes proliferation and migration of human fetal and adult dermal fibroblasts.

Purification of polysaccharides from Cordyceps militaris and their antihypoxic effect.

Potential regulatory molecules in the human trabecular meshwork of patients with glaucoma: immunohistochemical profile of a number of inflammatory cytokines.

Ephrin typeA receptor 2 regulates sensitivity to paclitaxel in nasopharyngeal carcinoma via the phosphoinositide 3kinase/Akt signalling pathway.

LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3kinase/Akt/fatty acid synthase signaling pathway in vitro.

Semaphorin 4D induces vaginal epithelial cell apoptosis to control mouse postnatal vaginal tissue remodeling.

Increased immunoreactivity of cFos in the spinal cord of the aged mouse and dog.

Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer.

Isolation and purification of oligopeptides from Ruditapes philippinarum and its inhibition on the growth of DU145 cells in vitro.

Effects of tetraspanin CD151 inhibition on A549 human lung adenocarcinoma cells.

Identification of differential splicing genes in gliomas using exon expression profiling.

A disintegrin and metalloproteinase 17 mRNA and protein expression in esophageal squamous cell carcinoma, as well as its clinicopathological factors and prognosis.

Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factorκB activation resulting in antioxidation.

Activated P2X7 receptor upregulates the expression levels of NALP3 in P388D1 murine macrophagelike cells.

Mitochondrial aldehyde dehydrogenase activity protects against lipopolysaccharideinduced cardiac dysfunction in rats.

Simvastatin enhances oxidizedlow density lipoproteininduced macrophage autophagy and attenuates lipid aggregation.

miR5423p overexpression is associated with enhanced osteosarcoma cell proliferation and migration ability by targeting Van Goghlike 2.

Increased serum amyloid A and its association with autoantibodies, acute phase reactants and disease activity in patients with rheumatoid arthritis.

Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats.

Skewed T-helper (Th)1/2- and Th17/T regulatorycell balances in patients with renal cell carcinoma.

Tracking of mesenchymal stem cells labeled with gadolinium diethylenetriamine pentaacetic acid by 7T magnetic resonance imaging in a model of cerebral ischemia.

microRNA99a inhibits cell proliferation, colony formation ability, migration and invasion by targeting fibroblast growth factor receptor 3 in prostate cancer.

Salvia miltiorrhiza injection restores apoptosis of fibroblast-like synoviocytes cultured with serum from patients with rheumatoid arthritis.

A simple method of catalase purification for the undergraduate experimental course.

Reprogramming rat embryonic fibroblasts into induced pluripotent stem cells using transposon vectors and their chondrogenic differentiation in vitro.

High glucose inhibits receptor activator of nuclear factorκB ligand-induced osteoclast differentiation via downregulation of vATPase V0 subunit d2 and dendritic cellspecific transmembrane protein.

Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA21.

Triptolide inhibits cell proliferation and tumorigenicity of human neuroblastoma cells.

Nearinfrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyes.

GABA(A) receptor overexpression in the lateral hypothalamic area attenuates gastric ischemiareperfusion injury in rats.

RhoV mediates apoptosis of RAW264.7 macrophages caused by osteoclast differentiation.

TAZ promotes epithelial to mesenchymal transition via the upregulation of connective tissue growth factor expression in neuroblastoma cells.

Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines.

Chondrogenic differentiation of human adiposederived stem cells using microcarrier and bioreactor combination technique.

GinsenosideRg5 induces apoptosis and DNA damage in human cervical cancer cells.

A study of the ultrasound-targeted microbubble destruction based triplex-forming oligodexinucleotide delivery system to inhibit tissue factor expression.

Lymphotoxin ß receptor activation promotes bladder cancer in a nuclear factor-κB-dependent manner.

Chloroquine inhibits MGC803 gastric cancer cell migration via the Toll-like receptor 9/nuclear factor kappa B signaling pathway.

Oscillatory potentials in electroretinogram as an early marker of visual abnormalities in vitamin A deficiency.

Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin1.

Differentiation of Schwannlike cells from human umbilical cord blood mesenchymal stem cells in vitro.

p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum.

Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ.

Identification of optimal reference genes for quantitative PCR studies on human mesenchymal stem cells.

MicroRNA-96 promotes the proliferation of colorectal cancer cells and targets tumor protein p53 inducible nuclear protein 1, forkhead box protein O1 (FOXO1) and FOXO3a.

Interaction between the human cytomegalovirusencoded UL142 and cellular Snapin proteins.

Protection of cultured human hepatocytes from hydrogen peroxideinduced apoptosis by relaxin3.

Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome.

Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion.

Metabolomics study on model rats of chronic obstructive pulmonary disease treated with BuFei JianPi.

Thalidomide combined with irradiation alters the activity of two proteases.

MicroRNA144 suppresses tumorigenesis of hepatocellular carcinoma by targeting AKT3.

Blockage of RelB expression by gene silencing enhances the radiosensitivity of androgenindependent prostate cancer cells.

Morphine protects SH-SY5Y human neuroblastoma cells against Dickkopf1-induced apoptosis.

Enhanced downregulation of transforming growth factorß2 in rat retinal pigment epithelium cells by adenoassociated virusmediated ribonucleic acid interference combined with ultrasound or microbubbles.

The role of death receptor 3 in the biological behavior of hepatocellular carcinoma cells.

Synergistic protective effects of escin and lowdose glucocorticoids against vascular endothelial growth factorinduced bloodretinal barrier breakdown in retinal pigment epithelial and umbilical vein endothelial cells.

microRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor Î³.

HIF1 signaling pathway involving iNOS, COX2 and caspase9 mediates the neuroprotection provided by erythropoietin in the retina of chronic ocular hypertension rats.

Exercise preconditioning alleviates brain damage via excitatory amino acid transporter 2 and extracellular signalregulated kinase 1/2 following ischemic stroke in rats.

Hiwi downregulation, mediated by shRNA, reduces the proliferation and migration of human hepatocellular carcinoma cells.

Integrin v promotes proliferation by activating ERK 1/2 in the human lung cancer cell line A549.

Identification of miR125a5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis.

Association of CYP3A4/5 genotypes and expression with the survival of patients with neuroblastoma.

Effect of immunosuppression on the human mesangial cell cycle.

Biological effect of ketamine in urothelial cell lines and global gene expression analysis in the bladders of ketamineinjected mice.

Human agerelated cataracts: epigenetic suppression of the nuclear factor erythroid 2related factor 2mediated antioxidant system.

Effects of antiviral therapy on the cellular immune response in patients with chronic hepatitis B.

Interleukin21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment.

Neutralizing antibodies respond to a bivalent dengue DNA vaccine or/and a recombinant bivalent antigen.

Bioinformatic analysis of microRNA expression in Parkinson's disease.

Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats.

Nemolike kinase expression predicts poor survival in colorectal cancer.

Arsenic sulfide as a potential anti-cancer drug

NMyc downstreamregulated gene 2 suppresses proliferation and induces oncosis of OSRC2 human renal cancer cells.

Effect of galectin-3 on the behavior of Eca109 human esophageal cancer cells.

Gene expression profiling of histologically normal breast tissue in females with human epidermal growth factor receptor 2positive breast cancer.

Synergetic effects of hBMSCs and hPCs in osteogenic differentiation and their capacity in the repair of critical-sized femoral condyle defects.

Ethanol extract of Forsythia suspensa root induces apoptosis of esophageal carcinoma cells via the mitochondrial apoptotic pathway.

Gel electrophoretic separation of proteins from cultured neuroendocrine tumor cell lines.

Heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by high glucose through the phosphoinositide 3kinase/Akt and extracellular signalregulated kinase 1/2 pathways.

Autologous plateletrich plasma promotes proliferation and chondrogenic differentiation of adiposederived stem cells.

miR107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1.

Selfassembled monolayers of alkanethiolates on surface chemistry groups in osteosarcoma cells.

Overexpression of the chimeric plasmin-resistant VEGF165/VEGF183 (132-158) protein in murine breast cancer induces distinct vascular patterning adjacent to tumors and retarded tumor growth.

Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis.

Interactions of connexin 43 and aquaporin-4 in the formation of glioma-induced brain edema.

Effects of engineered conserved dopamine neurotrophic factor-expressing bone marrow stromal cells on dopaminergic neurons following 6-OHDA administrations.

Astragalus and Paeoniae radix rubra extract inhibits liver fibrosis by modulating the transforming growth factor-β/Smad pathway in rats

Reduced ß2glycoprotein Ð inhibits hypoxiainduced retinal angiogenesis in neonatal mice through the vascular endothelial growth factor pathway.

Downregulation of nitric oxide by electroacupuncture against hypoxicischemic brain damage in rats via nuclear factorκB/neuronal nitric oxide synthase.

microRNA-338-3p functions as a tumor suppressor in human nonsmallcell lung carcinoma and targets Ras-related protein 14.

Simvastatin attenuates angiotensin IIinduced inflammation and oxidative stress in human mesangial cells.

Differentiation of human amniotic epithelial cells into Schwannlike cells via indirect coculture with Schwann cells in vitro.

Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression.

G-patch domain containing 2, a gene highly expressed in testes, inhibits nuclear factor-κB and cell proliferation.

Analysis of cytosine-adenine repeats in P1 promoter region of IGF-1 gene in peripheral blood cells and cervical tissue samples of females with cervical intraepithelial lesions and squamous cervical cancer

Resveratrol attenuates inflammation in the rat heart subjected to ischemia-reperfusion: Role of the TLR4/NF-κB signaling pathway.

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Effects of antiviral therapy on the cellular immune response in patients with chronic hepatitis B.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, Yanxiang Yan, Huiping Guo, Xiaolan Yi, Tingting Zhang, Guoyuan Luo, Guangcheng Feng, Xia Wang, Dongsheng
Description	Author Affiliation: Luo G ( Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.); Feng X ( Research Center for Infection and Immunity, Beijing You'an Hospital, Capital Medical University, Beijing 100069, P.R. China.); Huang Y ( Research Center for Infection and Immunity, Beijing You'an Hospital, Capital Medical University, Beijing 100069, P.R. China.); Yi T ( Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.); Wang D ( Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.); Guo X ( Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.); Yan H ( Research Center for Infection and Immunity, Beijing You'an Hospital, Capital Medical University, Beijing 100069, P.R. China.); Zhang G ( Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.)
Abstract	A weak Tcell immune response to the hepatitis B virus (HBV) is hypothesized to be the primary cause of chronic HBV infection. Emerging evidence suggests that longterm effective antiviral therapy restores the HBVspecific Tcell response from exhaustion. However, the extent to which the cellular immune response can be restored following the persistent suppression of HBV replication by antiviral therapy remains unclear. In order to investigate this question, 46 patients with chronic hepatitis B (CHB) treated with nucleos(t)ide analogues who demonstrated persistent suppression of HBV replication [defined as undetectable HBV DNA, hepatitis B e antigen (HBeAg) negative and adherence to antiviral therapy], 22 untreated CHB patients, 15 patients with acute hepatitis B (AHB) and 10 healthy adults were recruited. HBVspecific interferonÎ³ enzymelinked immunospot (IFNÎ³ ELISPOT) assay and HBVspecific Tcell proliferation analysis were performed with a panel of overlapping peptides covering the envelope and core antigens. Data from this study showed that the HBVspecific immune responses to the peptide pools of the envelope and core protein in the treated patients were stronger than those in the untreated CHB patients, but significantly weaker than those in the AHB patients and healthy adults. A higher frequency of response to S than C peptide pools was confirmed by the IFNÎ³ ELISPOT assay in the treated CHB patients. The restoration of antiviral immunity was clearly associated with a reduction in HBV DNA and the duration of HBV DNA suppression. In conclusion, the HBVspecific immune responses in the CHB patients can be significantly restored from exhaustion following the persistent suppression of HBV replication as a result of antiviral treatment with nucleos(t)ide analogues.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-02-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Antiviral Agents Therapeutic Use Hepatitis B, Chronic Drug Therapy Immunity, Cellular Cell Proliferation Dna, Viral Blood Enzyme-linked Immunospot Assay Genotype Hepatitis B e Antigens Hepatitis B Virus Genetics Metabolism Immunology Virology Drug Effects Leukocytes, Mononuclear Peptides Chemical Synthesis Pharmacology Polymerase Chain Reaction T-lymphocytes Cytology Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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