NDLI: Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats.

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Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats.

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Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Xue Han, Dong Yan, Jun Feng, Juan
Description	Author Affiliation: Yan J ( Department of Neurology, The Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.); Yang X ( Department of Neurology, The Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.); Han D ( Department of Neurology, The Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.); Feng J ( Department of Neurology, The Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.)
Abstract	Multiple sclerosis (MS) is an inflammatory autoimmune neurodegenerative disease, which features focal demyelination and inflammatory cell infiltration of the brain and the spinal cord. Tanshinone IIA (TSIIA), one of the major fatsoluble components of Salvia miltiorrhiza (Danshen), has antiinflammatory, immunoregulatory and neuroprotective activity; however, its efficacy in MS remains unknown. The current study was designed to investigate the potential therapeutic function of TSIIA on MS in the experimental autoimmune encephalomyelitis (EAE) rat model. In comparison to the vehicle control group, the TSIIAtreated groups showed notably improved clinical symptoms and pathological changes, including central nervous system inflammatory cell infiltration and demyelination. Following administration of TSIIA, the quantity of CD4+ T cells, CD8+ T cells and macrophages/microglia in the spinal cord were reduced to different extents. Furthermore, TSIIA was also shown to downregulate interleukin (IL)17 and IL23 levels in the brain and serum of EAE rats. The results collectively provide evidence that TSIIA alleviates EAE and support its utility as a novel therapy for MS.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5431
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	14
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-08-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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