NDLI: Ipr1 modified BCG as a novel vaccine induces stronger immunity than BCG against tuberculosis infection in mice.

Please wait, while we are loading the content...

Year: 2017 Volume: 15

Year: 2016 Volume: 14

Year: 2016 Volume: 14 Issue: 6

Year: 2016 Volume: 14 Issue: 5

Year: 2016 Volume: 14 Issue: 4

Year: 2016 Volume: 14 Issue: 3

Year: 2016 Volume: 14 Issue: 2

Mangiferin inhibits macrophage classical activation via downregulating interferon regulatory factor 5 expression.

Effect of glucocorticoids on osteoclast function in a mouse model of bone necrosis.

Upregulation of microRNA-206 enhances lipopolysaccharide-induced inflammation and release of amyloid-ß by targeting insulin-like growth factor 1 in microglia.

Autophagic death induced by thermochemotherapy in gastric cancer cells results from the reactive oxygen species pathway.

Hydroxychloroquine protects melanocytes from autoantibody-induced injury by reducing the binding of antigen-antibody complexes.

MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase.

Adenovirus with p16 gene exerts antitumor effect on laryngeal carcinoma Hep2 cells.

Clinical significance of RET mutation screening in a pedigree of multiple endocrine neoplasia type 2A.

N-ethylmaleimidesensitive factor siRNA inhibits the release of Weibel-Palade bodies in endothelial cells.

RUNX2 controls human IPO8 basal transcription in Saos-2 cells.

COP1 is downregulated in renal cell carcinoma (RCC) and inhibits the migration of RCC ACHN cells in vitro.

Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling.

Immunolocalization of MMP9 and MMP2 in osteolytic metastasis originating from MDA-MB-231 human breast cancer cells.

Modified Pulsatilla decoction attenuates oxazolone-induced colitis in mice through suppression of inflammation and epithelial barrier disruption.

A genome wide analysis of alternative splicing events during the osteogenic differentiation of human cartilage endplate-derived stem cells.

PRDM8 internal promoter hyperhydroxymethylation correlates with increased expression of the corresponding transcript in Down syndrome.

Identification and characteristics of the testes-specific gene, Ccdc38, in mice.

De novo sequencing and analysis of the transcriptome of Panax ginseng in the leaf-expansion period.

MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo.

Icariin promotes cell proliferation and regulates gene expression in human neural stem cells in vitro.

Roscovitine ameliorates endotoxin-induced uveitis through neutrophil apoptosis.

Sirtuin 1 promotes the proliferation of C2C12 myoblast cells via the myostatin signaling pathway.

Protective effects of BMSCs in combination with erythropoietin in bronchopulmonary dysplasia-induced lung injury.

Shikonin stimulates MC3T3-E1 cell proliferation and differentiation via the BMP-2/Smad5 signal transduction pathway.

Expression of miR-199a-3p in human adipocytes is regulated by free fatty acids and adipokines.

Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma.

Ag85A/ESAT-6 chimeric DNA vaccine induces an adverse response in tuberculosis-infected mice.

Human GPR4 and the Notch signaling pathway in endothelial cell tube formation.

Histone acetylation is involved in TCDDinduced cleft palate formation in fetal mice.

Effects of 17-AAG on the cell cycle and apoptosis of H446 cells and the associated mechanisms.

Secretory leukocyte protease inhibitor promotes differentiation and mineralization of MC3T3-E1 preosteoblasts on a titanium surface.

Genomic expression profiling and bioinformatics analysis on diabetic nephrology with ginsenoside Rg3.

Latent cytomegalovirus infection exacerbates experimental pulmonary fibrosis by activating TGF-ß1.

Anxiolytic and neuroprotective effects of the Traditional Chinese Medicinal formulation Dan-zhi-xiao-yao-san in a rat model of chronic stress.

Molecular docking studies of Traditional Chinese Medicinal compounds against known protein targets to treat non-small cell lung carcinomas.

Induction of adipose-derived stem cells into Schwann-like cells and observation of Schwann-like cell proliferation.

Identification and association of RAC1 gene polymorphisms with mRNA and protein expression levels of Rac1 in solid organ (kidney, liver, heart) transplant recipients.

Paeoniflorin ameliorates acute necrotizing pancreatitis and pancreatitisinduced acute renal injury.

ANRIL is associated with the survival rate of patients with colorectal cancer, and affects cell migration and invasion in vitro.

CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.

Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation.

CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma.

Abnormal osteogenic and chondrogenic differentiation of human mesenchymal stem cells from patients with adolescent idiopathic scoliosis in response to melatonin.

HMGB1 promotes cellular chemokine synthesis and potentiates mesenchymal stromal cell migration via Rap1 activation.

Transforming growth factor-ß1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway.

Flowers of Camellia nitidissima cause growth inhibition, cell-cycle dysregulation and apoptosis in a human esophageal squamous cell carcinoma cell line.

Upregulation of p27Kip1 by demethylation sensitizes cisplatin-resistant human ovarian cancer SKOV3 cells.

Flavonoids from Radix Tetrastigmae improve LPS-induced acute lung injury via the TLR4/MD-2-mediated pathway.

Isolation, culture, purification and ultrastructural investigation of cardiac telocytes.

Recombinant human brain natriuretic peptide attenuates LPS-induced cellular injury in human fetal lung fibroblasts via inhibiting MAPK and NF-κB pathway activation.

Methylation status of the promoter region of the human frizzled 9 gene in acute myeloid leukemia.

Silencing cyclin-dependent kinase inhibitor 3 inhibits the migration of breast cancer cell lines.

Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro.

microRNA-208a in an early stage myocardial infarction rat model and the effect on cAMP-PKA signaling pathway.

NR2F2 regulates bone marrow-derived mesenchymal stem cell-promoted proliferation of Reh cells.

Differentially expressed microRNA-218 modulates the viability of renal cell carcinoma by regulating BCL9.

Neurogenesis-based epigenetic therapeutics for Alzheimer's disease (Review).

MBD2 as a novel marker associated with poor survival of patients with hepatocellular carcinoma after hepatic resection.

Aberrant Notch signaling in glioblastoma stem cells contributes to tumor recurrence and invasion.

Jia-Shen decoction-medicated serum inhibits angiotensin-II induced cardiac fibroblast proliferation via the TGF-ß1/Smad signaling pathway.

Overexpression of Dlx2 leads to postnatal condyle degradation.

Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity.

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Soy milk digestion extract inhibits progression of prostate cancer cell growth via regulation of prostate cancerspecific antigen and cell cycle-regulatory genes in human LNCaP cancer cells.

Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet.

Inhibition of microRNA-155 sensitizes lung cancer cells to irradiation via suppression of HK2-modulated glucose metabolism.

Using cysteine/cystine to overcome oxidative stress in goat oocytes and embryos cultured in vitro.

Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1ß and MMP-13.

Oncogenic role of microRNA20a in human uveal melanoma.

Ipr1 modified BCG as a novel vaccine induces stronger immunity than BCG against tuberculosis infection in mice.

Identification of differentially expressed genes between lung adenocarcinoma and lung squamous cell carcinoma by gene expression profiling.

Screening targeted testisspecific genes for molecular assessment of aberrant sperm quality.

MicroRNA335 inhibits bladder cancer cell growth and migration by targeting mitogenactivated protein kinase 1.

miR-200b inhibits migration and invasion in non-small cell lung cancer cells via targeting FSCN1.

Decreasing the ratio of matriptase/HAI1 by downregulation of matriptase as a potential adjuvant therapy in ovarian cancer.

Aspirin inhibits glucose6phosphate dehydrogenase activity in HCT 116 cells through acetylation: Identification of aspirin-acetylated sites.

Biological effects of eukaryotic recombinant plasmid pReceiver-M61-BAI-1 transfection on T24 cells and HUVECs.

Mechanism of uncoupling protein 2mediated myocardial injury in hypothermic preserved rat hearts.

Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells.

Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis.

Decreased expression of Beclin1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma.

Protein kinase C is involved in the regulation of AXL receptor tyrosine kinase expression in triple-negative breast cancer cells.

Sphingosine 1phosphate induced by hypoxia increases the expression of PAI1 in HepG2 cells via HIF1 .

CMPNacetylneuraminic acid synthetase interacts with fragile X related protein 1.

Neonatal Bacillus Calmette-Guérin vaccination alleviates lipopolysaccharide-induced neurobehavioral impairments and neuroinflammation in adult mice.

Type II cGMPdependent protein kinase inhibits EGFinduced JAK/STAT signaling in gastric cancer cells.

A recombinant plasmid containing CpG motifs as a novel vaccine adjuvant for immune protection against herpes simplex virus 2.

Bufalin reverses intrinsic and acquired drug resistance to cisplatin through the AKT signaling pathway in gastric cancer cells.

Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells.

S100A1 transgenic treatment of acute heart failure causes proteomic changes in rats

Role of GLTSCR2 in the regulation of telomerase activity and chromosome stability.

Functional properties of DENV EDIIIreactive antibodies in human DENV1infected sera and rabbit antiserum to EDIII.

GSK-3ß inhibitor attenuates urinary albumin excretion in type 2 diabetic db/db mice, and delays epithelial-to-mesenchymal transition in mouse kidneys and podocytes.

Characterization of human bone morphogenetic protein gene variants for possible roles in congenital heart disease.

miR-20a induces cisplatin resistance of a human gastric cancer cell line via targeting CYLD.

The angiogenic effect of dracorhodin perchlorate on human umbilical vein endothelial cells and its potential mechanism of action.

The de novo missense mutation N117S in skeletal muscle actin 1 causes a mild form of congenital nemaline myopathy.

Positive association of the androgen receptor CAG repeat length polymorphism with the risk of prostate cancer.

Loss of membranous VEGFR1 expression is associated with an adverse phenotype and shortened survival in breast cancer.

Reciprocal regulation of long noncoding RNAs THBS4003 and THBS4 control migration and invasion in prostate cancer cell lines.

Contribution of human osteoblasts and macrophages to bone matrix degradation and proinflammatory cytokine release after exposure to abrasive endoprosthetic wear particles.

Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats.

Effects of AP1 and NFκB inhibitors on colonic endocrine cells in rats with TNBSinduced colitis.

Low levels of TGF-ß1 enhance human umbilical cord-derived mesenchymal stem cell fibronectin production and extend survival time in a rat model of lipopolysaccharide-induced acute lung injury.

Polydatin possesses notable antiosteoporotic activity via regulation of OPG, RANKL and ßcatenin.

Vitamin E succinate induces apoptosis via the PI3K/AKT signaling pathways in EC109 esophageal cancer cells.

Mechanism of osteogenic and adipogenic differentiation of tendon stem cells induced by sirtuin 1.

IL33/ST2 pathway in a bleomycininduced pulmonary fibrosis model.

Importance of activated hepatic stellate cells and angiopoietin-1 in the pathogenesis of hepatocellular carcinoma.

Year: 2016 Volume: 14 Issue: 1

Year: 2016 Volume: 13

Year: 2015 Volume: 12

Year: 2015 Volume: 11

Year: 2014 Volume: 10

Year: 2014 Volume: 9

Year: 2013 Volume: 8

Year: 2013 Volume: 7

Year: 2012 Volume: 6

Year: 2012 Volume: 5

Year: 2011 Volume: 4

Year: 2010 Volume: 3

Year: 2008 Volume: 1

Ipr1 modified BCG as a novel vaccine induces stronger immunity than BCG against tuberculosis infection in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhan, Xingxing Xu, Lei Yang, Chun He, Yonglin Wang, Yuwei
Description	Author Affiliation: Wang Y ( Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, P.R. China.); Yang C ( Department of Microbiology, Chongqing Medical University, Chongqing 400016, P.R. China.); He Y ( Department of Microbiology, Chongqing Medical University, Chongqing 400016, P.R. China.); Zhan X ( Department of Pediatrics, Chongqing Medical University, Chongqing 400016, P.R. China.); Xu L ( Department of Microbiology, Chongqing Medical University, Chongqing 400016, P.R. China.)
Abstract	Tuberculosis is a major challenge to global public health. However, the Bacille CalmetteGuérin (BCG), the only vaccine available against tuberculosis, has been questioned for the low protective effect. The present study used the mouse gene intracellular pathogen resistance I (Ipr1) gene to alter the current BCG vaccine and evaluated its immunity effect against tuberculosis. This study also investigated the intrinsic relationships of Ipr1 and innate immunity. The reformed BCG (BCGi) carrying the Ipr1 gene was constructed. The mice were intranasally challenged with the M. tuberculosis H37Rv strain after vaccination with BCGi. Protection efficacy of the vaccine was assessed by the organ coefficient, bacterial load and pathological changes in the lung. The differential expression of 113 immunerelated genes between BCGi and BCG groups were detected by an oligo microarray. According to the results of organ coefficient, bacterial load and pathological changes in the organization, BCGi had been shown to have stronger protective effects against M. tuberculosis than BCG. The oligo microarray and reverse transcriptionquantitative polymerase chain reaction further revealed that the Ipr1 gene could upregulate the expression of 13 genes, including a >3fold increase in Tolllike receptor (TLR)4 and 10fold increase in surfactant protein D (sftpd). The two genes not only participate in innate immunity against pathogens, but also are closely interrelated. Ipr1 could activate the TLR4 and sftpd signaling pathway and improve the innate immunity against tuberculosis, therefore Ipr1 modified BCG may be a candidate vaccine against M. tuberculosis.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	14
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-08-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in