NDLI: Therapeutic effects of paeonol on methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson's disease in mice.

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Therapeutic effects of paeonol on methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson's disease in mice.

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Therapeutic effects of paeonol on methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson's disease in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Hao Qu, Hong-Dang Shi, Xiaojin Chen, Yu-Hua
Description	Author Affiliation: Shi X ( Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.); Chen YH ( Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.); Liu H ( Department of Pharmacy, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.); Qu HD ( Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.)
Abstract	Paeonol is a major phenolic compound of the Chinese herb, Cortex Moutan, and is known for its antioxidant, anti-inflammatory and antitumor properties. The present study was designed to investigate the therapeutic potential and underlying mechanisms of paeonol on a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced mouse model of Parkinson's disease (PD). MPTP (25 mg/kg), followed by probenecid (250 mg/kg), was administered via i.p. injection for five consecutive days to induce the mouse model of PD. Paeonol (20 mg/kg) was administrated orally for 21 days. Behavior was assessed using the rotarod performance and openfield tests. Additionally, the levels of tyrosine hydroxylase (TH), microglia, interleukin1ß (IL1ß), and brainderived neurotrophic factor (BDNF) in the substantia nigra pars compacta (SNpc) were evaluated by immunohistochemical staining. MPTP/pinduced motor deficits were observed to be significantly improved following longterm treatment with paeonol. Paeonol treatment decreased MPTP/pinduced oxidative stress, as determined by evaluating the activity levels of superoxide dismutase, catalase and glutathione. Additionally, MPTP/pinduced neuroinflammation was assessed by examining the levels of microglia and IL1ß, which were significantly decreased following paeonol treatment. Paeonol treatment improved the MPTP/pinduced dopaminergic neurodegeneration, as measured by observing the increased TH level in the SNpc. Furthermore, the BDNF level was significantly elevated in the paeonol treatment group compared with mice treated with MPTP/p only. In conclusion, paeonol exerted therapeutic effects in the MPTP/pinduced mouse model of PD, possibly by decreasing the damage from oxidative stress and neuroinflammation, and by enhancing the neurotrophic effect on dopaminergic neurons. The results demonstrate paeonol as a potential novel treatment for PD.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5573
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	14
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-09-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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