NDLI: Zoledronic acid overcomes adriamycin resistance in acute myeloid leukemia cells by promoting apoptosis.

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Zoledronic acid overcomes adriamycin resistance in acute myeloid leukemia cells by promoting apoptosis.

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Zoledronic acid overcomes adriamycin resistance in acute myeloid leukemia cells by promoting apoptosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Xiang-Fu Guo, Xiao-Yan Lin, Dong-Jun Lu, Ying Fan, Rui-Fang Fang, Zhi-Gang Chen, Yu-Xin Xu, Yi-Chuan Liu, Ling-Ling
Description	Author Affiliation: Fan RF ( Department of Hematology, The Third Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Chen YX ( Department of Hematology, The Third Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Fang ZG ( Department of Hematology, The Third Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Guo XY ( Department of Pediatrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong 510010, P.R. China.); Lu Y ( Department of Blood Transfusion, The Third Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Liu LL ( Department of Hematology, The Third Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Xu YC ( Department of Hematology, The Third Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Liu XF ( Department of Blood Transfusion, The Third Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.); Lin DJ ( Department of Hematology, The Third Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510630, P.R. China.)
Abstract	Zoledronic acid (ZOL), a nitrogencontaining bisphosphonate, is widely used in metastatic bone disease. Previous studies indicate that ZOL has marked antileukemia activity, however, the underlying mechanism of action remains to be elucidated. The present study aimed to explore the mechanism of the antileukemia effect of ZOL in leukemia cells. It was observed that ZOL inhibited the proliferation of HL60 and adriamycinresistant HL60 (HL60/A) cells using a WST8 assay. An Annexin Vpropidium iodide indicated that ZOL induced apoptosis of the two cell types in a dose and timedependent manner. Hoechst 33342 staining was also used to verify the levels of apoptosis. The colony formation assay demonstrated that ZOL significantly inhibited colony formation capacity in acute myeloid leukemia (AML) cells. This was achieved by the induction of Sphase cell cycle arrest, downregulation of Bcell lymphoma 2 (Bcl2) and upregulation of Bcl2 associated X protein and cleaved poly (ADPribose) polymerase. The results indicate that ZOL inhibited cell proliferation by inducing apoptosis via the mitochondrial apoptotic pathway and this antileukemic activity appeared notably enhanced in HL60/A cells. As ZOL is already available for clinical use, these results indicate that it may be an effective addition to the chemotherapeutic strategies for AML.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	14
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-12-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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