NDLI: Association between the angiotensin converting enzyme gene insertion/deletion polymorphism and metabolic disturbances in women with polycystic ovary syndrome.

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Association between the angiotensin converting enzyme gene insertion/deletion polymorphism and metabolic disturbances in women with polycystic ovary syndrome.

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Association between the angiotensin converting enzyme gene insertion/deletion polymorphism and metabolic disturbances in women with polycystic ovary syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ozegowska, Katarzyna Pawelczyk, Leszek Bartkowiak-Wieczorek, Joanna Seremak-Mrozikiewicz, Agnieszka Bogacz, Anna
Description	Country affiliation: Poland Author Affiliation: Ozegowska K ( Department of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 60535 Poznan, Poland.); Bogacz A ( Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, 61707 Poznan, Poland.); Bartkowiak-Wieczorek J ( Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, 61707 Poznan, Poland.); Seremak-Mrozikiewicz A ( Laboratory of Molecular Biology, Division of Perinatology and Women's Diseases, Poznan University of Medical Sciences, 60535 Poznan, Poland.); Pawelczyk L ( Department of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 60535 Poznan, Poland.)
Abstract	Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. A number of PCOS complications may be associated with the elevated level of angiotensin II and low bradykinin concentrations. The aim of the present study was to investigate the frequencies of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms in women with PCOS and to determine the association between ACE genetic variants and the risk of metabolic and cardiovascular complications in such women. A total of 138 PCOS patients and 110 healthy volunteers were enrolled. Cardiovascular risk was estimated according to the criteria of the American Heart Association and Androgen Excess and PCOS Society. The median average age was 28.5 (26.031.0) and 27.0 (24.030.0) years in the control and PCOS groups, respectively (P=0.004). Anthropometric parameters, including body mass index and waist circumference were significantly higher in the PCOS patients. In the PCOS group, 97 (57.4%) of the subjects were metabolically unhealthy, whereas, in the control group 51 (46.4%) subjects were (P=0.07). The II, ID, and DD genotypes frequencies were 29.1, 44.5, and 26.4% in the controls and 5.0, 37.7, and 57.3% in the PCOS patients. The cardioprotective I allele was observed significantly less frequently in the women with PCOS compared with the controls [odds ratio (OR), 3.27; P=0.0001]. The DD genotype, which is known to increase cardiovascular risk, was more frequently observed in PCOS patients (OR, 3.87; P=0.0003), whereas the cardioprotective II genotype occurred in this group less frequently (OR, 0.4; P=0.06). The results of the present study demonstrated a statistically significant association between the ACE I/D polymorphism and the presence and intensity of metabolic disturbances in women with PCOS.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	14
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-12-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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