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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Heil, Patrick Spatz, Joachim P. |
| Description | Country affiliation: Germany Author Affiliation: Heil P ( Department of New Materials and Biosystems, Max Planck Institute for Metals Research, Stuttgart, Germany.) |
| Abstract | Focal adhesions (FAs) are important adhesion sites between eukaryotic cells and the extracellular matrix, their size depending on the locally applied force. To quantitatively study the mechanosensitivity of FAs, we induce their growth and disassembly by varying the distribution of intracellular stress. We present a novel method for micromanipulation of living cells to explore the dynamics of focal adhesion (FA) assembly under force. Fibroblasts are sheared laterally to their adhesion surface with single PDMS micropillars in order to apply laterally stretch or compression to focal adhesions. This allows for measuring the shear force exerted by the micropillar and correlates it with FA length and growth velocity. Furthermore, we analyze the resulting dynamics of FA molecules (paxillin) and compare intensity profiles along FAs before and after the application of external force. The responses of stretched and relaxed FAs differ fundamentally: relaxed and compressed FAs disassemble isotropically and show no length variation while stretched FAs grow unisotropically in the direction of the applied force and show protein influx only at their front. |
| ISSN | 09538984 |
| e-ISSN | 1361648X |
| DOI | 10.1088/0953-8984/22/19/194108 |
| Journal | Journal of Physics: Condensed Matter |
| Issue Number | 19 |
| Volume Number | 22 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2010-05-19 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Cell Adhesion Physiology Fibroblasts Focal Adhesions Mechanotransduction, Cellular Micromanipulation Animals Cell Line Shear Strength Stress, Mechanical Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Condensed Matter Physics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Condensed Matter Physics Materials Science |
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