| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Yu, Xiaohong Si, Wenhui Zhou, Yingjun Xu, Bingqing Hong, Fashui Zhao, Xiaoyang Ze, Yuguan Zhang, Jianhao Hong, Jie Sheng, Lei Liu, Dong Wang, Ling |
| Description |
Author Affiliation: Hong F ( Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, Huaiyin Normal University, Huaian 223300, China); Zhao X ( Medical College of Soochow University, Suzhou 215123, China.); Si W ( Key Laboratory of Agricultural and Animal Products Processing and Quality Control, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China); Ze Y ( Medical College of Soochow University, Suzhou 215123, China.); Wang L ( Library of Soochow University, Suzhou 215123, China.); Zhou Y ( Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, Huaiyin Normal University, Huaian 223300, China); Hong J ( Medical College of Soochow University, Suzhou 215123, China.); Yu X ( Medical College of Soochow University, Suzhou 215123, China.); Sheng L ( Medical College of Soochow University, Suzhou 215123, China.); Liu D ( Medical College of Soochow University, Suzhou 215123, China.); Xu B ( Medical College of Soochow University, Suzhou 215123, China.); Zhang J ( Key Laboratory of Agricultural and Animal Products Processing and Quality Control, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: nau_zjh@njau.edu.cn.) |
| Abstract |
Although TiO2 nanoparticles (NPs) exposure has been demonstrated to cross blood-testis barrier and accumulate in the testis resulting in the reduction of sperm numbers, limited data with respect to the molecular mechanism of decreased spermatogenesis caused by TiO2 NP exposure. In this research, testicular damage, sperm number and alterations in testis-specific gene expressions in male mice induced by intragastric administration with TiO2 NPs for six months were investigated. It was found out that TiO2 NPs could migrate to cells, deposit in the testis and epididymis and thus cause damages to relevant organs, which are, to be more specific, the reductions of total sperm concentrations and sperm motility and an enhancement in the number of abnormal sperms in the cauda epididymis. Furthermore, the individual expression regarding to the mRNAs and proteins of testis-specific genes, including Cdc2, Cyclin B1, Dmcl, TERT, Tesmin, TESP-1, XPD and XRCCI, were significantly declined, whereas Gsk3-ß and PGAM4 expressions were greatly elevated in mouse testis due to the exposures, which in fact implied that the reduced spermatogenesis may be involved in the alternated testis-specific gene expressions in those exposed male mice. |
| ISSN |
03043894 |
| Volume Number |
300 |
| e-ISSN |
18733336 |
| Journal |
Journal of Hazardous Materials |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2015-12-30 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Gene Expression Drug Effects Nanoparticles Toxicity Spermatogenesis Testis Metabolism Titanium Animals Body Weight Epididymis Male Mice Mice, Inbred Icr Semen Cytology Spermatozoa Journal Article Research Support, Non-u.s. Gov't Discipline Environmental Science Discipline Environmental Chemistry |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Environmental Chemistry Pollution Waste Management and Disposal Health, Toxicology and Mutagenesis Environmental Engineering |
