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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Doussineau, Tristan Grund, Stefan Mohr, Gerhard J. Fischer, Dagmar |
| Description | Country affiliation: Germany Author Affiliation: Grund S ( Department of Pharmaceutical Technology, Friedrich Schiller University of Jena, Otto-Schott-Strasse 41, D-07745 Jena, Germany.) |
| Abstract | This article describes the preparation and the physico-chemical characterization of a new host-guest system consisting of zeolite beta nanoparticles as host and mitoxantrone as guest. The resulting host-guest system mitoxantrone@beta is characterized in terms of morphology (transmission electron microscopy, dynamic light scattering), structure (powder wide-angle X-ray diffraction, nitrogen sorption), surface charge (ξ-potential measurements), and optical properties (UV-visible absorption, steady-state fluorescence). Mitoxantrone@beta particles are monodisperse in size with a mean diameter centered around 100 nm. Mitoxantrone guest molecules are adsorbed at the micropore entrances of zeolite host. Resulting nanoparticles retrieve the interesting optical properties of guest molecules with a fluorescence emission band in the near-infrared region. Mitoxantrone loading is comparatively evaluated by three different means (elemental analysis, direct and indirect UV-visible absorption studies) showing a loading level of 6.8 µmol/g. Mitoxantrone@beta nanoparticles also show a noticeable cytotoxic effect when applied to cancer cells. |
| ISSN | 00219797 |
| Issue Number | 1 |
| Volume Number | 365 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antineoplastic Agents Drug Carriers Mitoxantrone Nanoparticles Chemistry Zeolites Pharmacology Cell Line, Tumor Drug Screening Assays, Antitumor Methods Humans Mandatory Testing Particle Size Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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