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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Luan, Jingjing Yang, Xiaoye Chu, Lianjun Zhai, Guangxi Xi, Yanwei |
| Description | Country affiliation: China Author Affiliation: Luan J ( Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.); Yang X ( Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.); Chu L ( College of Medicine and Nursing, Dezhou University, Dezhou 253023, China.); Xi Y ( Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.); Zhai G ( Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China. Electronic address: professorgxzhai@126.com.) |
| Abstract | Amoitone B is a newly synthesized derivative of antitumor drug cytosporone B, which exhibits excellent anticancer activity in vivo. Nevertheless, the water-insolubility and short biological half-life limit its further development. In the present study, polyethylene glycol-modified, Amoitone B-loaded long circulating nanostructured lipid carriers (AmB-PEG-NLC) were prepared by the emulsion-evaporation and low temperature-solidification method. The in vitro antitumor activity and intracellular uptake of AmB-PEG-NLC in the human colon cancer SW620 cells and liver cancer HepG2 cells were evaluated in detail. MTT assay was employed to investigate the inhibition effect on cellular viability. Propidium iodide and DAPI staining were performed to visually examine the fluorescent morphology changes of the cells incubated with AmB-PEG-NLC. Flow cytometry was utilized to determine the influence of AmB-PEG-NLC on apoptosis of SW620. The intracellular uptake was observed by rhodamine B, a fluorescent maker. Cytotoxicity assay, observation of morphological changes and apoptosis examination revealed that AmB-PEG-NLC could markedly enhance the cytotoxicity of AmB against cancer cell compared to AmB solution and AmB-NLC. An increased uptake of PEG-NLC was obtained compared with NLC in SW620 cells, which might attribute to the effect of PEG. Based on these results, AmB-PEG-NLC could be a promising delivery system for AmB with effective cancer therapy. |
| ISSN | 00219797 |
| Volume Number | 428 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-08-15 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antineoplastic Agents Administration & Dosage Drug Carriers Chemistry Nanostructures Phenylacetates Polyethylene Glycols Pharmacokinetics Pharmacology Apoptosis Drug Effects Cell Line, Tumor Colonic Neoplasms Drug Therapy Hep G2 Cells Humans Liver Neoplasms Particle Size Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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