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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Parhi, Priyambada Sahoo, Sanjeeb Kumar |
| Description | Country affiliation: India Author Affiliation: Parhi P ( Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar, India.); Sahoo SK ( Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar, India. Electronic address: sanjeebsahoo2005@gmail.com.) |
| Abstract | Nowadays, emerging aspects of cancer therapy involve both diagnostic and therapeutic modules in a single setting. Targeted theranostic nanoplatforms have emerged globally as frontier research for the improvement of cancer therapy. Trastuzumab (Tmab), a humanized monoclonal antibody is now being used to target human epidermal growth factor receptor-2 (HER 2) positive cancer cells. In the present study, we have analysed the imaging and theragnosis potentiality of Tmab functionalized lipid based nanoparticles (NPs) loaded with anticancer drug rapamycin and imaging agent (quantum dots) for targeted cancer therapy and imaging. The therapeutic evaluation of drug loaded NPs were evaluated through various in vitro cellular studies. The results showed enhanced therapeutic efficacy of targeted drug loaded NPs over native drug and unconjugated NPs in HER 2 positive SKBR 3 breast cancer cell line. Moreover, exploration of the therapeutic benefits of rapamycin loaded Tmab conjugated NPs (Tmab-rapa-NPs) at molecular level, revealed augmented down regulation of mTOR signalling pathway thereby, inducing more cell death. Above all, our targeted multifunctional NPs have shown an excellent bio-imaging modality both in 2D monolayer and 3D tumor spheroid model. Thus, we can anticipate that such a multimodal nanotheranostic approach may be a useful tool for better cancer management in future. |
| ISSN | 00219797 |
| Volume Number | 451 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antibiotics, Antineoplastic Administration & Dosage Breast Neoplasms Diagnosis Drug Therapy Nanoparticles Metabolism Receptor, Erbb-2 Sirolimus Trastuzumab Pharmacology Breast Drug Effects Pathology Cell Line, Tumor Cell Survival Drug Delivery Systems Female Humans Lipids Chemistry Quantum Dots Tor Serine-threonine Kinases Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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