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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Zihao Chen, Ning Qu, Yanming Gu, Wei Li, Shuai Ye, Ling Yu, Chunjiang Shao, Chen |
| Description | Author Affiliation: Chen N ( Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China.); Shao C ( School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.); Li S ( School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.); Wang Z ( School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, PR China.); Qu Y ( Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, PR China.); Gu W ( School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China. Electronic address: weigu@ccmu.edu.cn.); Yu C ( Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, PR China. Electronic address: cjyu1955@sina.com.); Ye L ( School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China. Electronic address: lingye@ccmu.edu.cn.) |
| Abstract | The fusion of molecular and anatomical modalities facilitates more reliable and accurate detection of tumors. Herein, we prepared the PEG-Cy5.5 conjugated MnO nanoparticles (MnO-PEG-Cy5.5 NPs) with magnetic resonance (MR) and near-infrared fluorescence (NIRF) imaging modalities. The applicability of MnO-PEG-Cy5.5 NPs as a dual-modal (MR/NIRF) imaging nanoprobe for the detection of brain gliomas was investigated. In vivo MR contrast enhancement of the MnO-PEG-Cy5.5 nanoprobe in the tumor region was demonstrated. Meanwhile, whole-body NIRF imaging of glioma bearing nude mouse exhibited distinct tumor localization upon injection of MnO-PEG-Cy5.5 NPs. Moreover, ex vivo CLSM imaging of the brain slice hosting glioma indicated the preferential accumulation of MnO-PEG-Cy5.5 NPs in the glioma region. Our results therefore demonstrated the potential of MnO-PEG-Cy5.5 NPs as a dual-modal (MR/NIRF) imaging nanoprobe in improving the diagnostic efficacy by simultaneously providing anatomical information from deep inside the body and more sensitive information at the cellular level. |
| ISSN | 00219797 |
| Volume Number | 457 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Brain Pathology Carbocyanines Chemistry Glioma Diagnosis Magnetic Resonance Imaging Manganese Compounds Molecular Imaging Nanoparticles Oxides Animals Administration & Dosage Contrast Media Fluorescence Infrared Rays Male Mice Mice, Nude Neoplasms, Experimental Particle Size Polyethylene Glycols Surface Properties Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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