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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Manavis, Jim Hayball, John D. Cavallaro, Alex Mierczynska, Agnieszka Bachhuka, Akash Smith, Louise E. Vasilev, Krasimir Diener, Kerrilyn R. Marian, Romeo Christo, Susan N. |
| Description | Country affiliation: Australia Author Affiliation: Bachhuka A ( Mawson Institute, University of South Australia, Adelaide, SA 5000, Australia.); Christo SN ( Experimental Therapeutics Laboratory, Royal Adelaide Hospital, Adelaide, SA 5000, Australia); Cavallaro A ( Mawson Institute, University of South Australia, Adelaide, SA 5000, Australia); Diener KR ( Experimental Therapeutics Laboratory, Royal Adelaide Hospital, Adelaide, SA 5000, Australia); Mierczynska A ( The Australian Wine Research Institute, Urrbrae, Adelaide, SA 5000, Australia.); Smith LE ( Mawson Institute, University of South Australia, Adelaide, SA 5000, Australia); Marian R ( School of Engineering, University of South Australia, Adelaide, SA 5000, Australia.); Manavis J ( Centre for Neurological Diseases, SA Pathology, Adelaide, SA 5000, Australia.); Hayball JD ( Experimental Therapeutics Laboratory, Royal Adelaide Hospital, Adelaide, SA 5000, Australia); Vasilev K ( Mawson Institute, University of South Australia, Adelaide, SA 5000, Australia) |
| Abstract | Hybrid micro and nanoparticles have become a topic of intense research in recent years. This is due to the special properties of these materials that open new avenues in advanced applications. Herein, we report a novel method for the generation of hybrid particles utilising plasma polymerization. Poly (methyl methacrylate) (PMMA) beads were first coated with a thin allylamine based plasma polymer layer. Gold nanoparticles of engineered size and surface structure were then attached in a controlled manner to the plasma polymer coated beads. To generate uniform chemistry on the outermost surface and to preserve the nanotopography, we deposited a 5-10 nm thin layer of Acpp. We demonstrated that these particles can be utilized in in vivo models to interrogate important biological phenomena. Specifically, we used them in mice to study the inflammatory and foreign body responses to surface nanotopography. The data strongly indicates that surface nanotopography and chemistry can modulate collagen production and the number of adhering immune cells. The method for generating hybrid particles reported here is solvent free and can open new opportunities in fields such as tissue engineering, drug delivery, biosensors, and regenerative medicine. |
| ISSN | 00219797 |
| Volume Number | 457 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Allylamine Chemistry Gold Inflammation Metabolism Metal Nanoparticles Microchemistry Polymethyl Methacrylate Animals Foreign-body Reaction Mice Mice, Inbred C57bl Particle Size Surface Properties Journal Article Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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