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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nedellec, Steven Lartigue, Lénaïc Dubreil, Laurence Hulin, Philippe Doussineau, Tristan Fleury, Fabrice Antoine, Rodolphe Benhelli-Mokrani, Houda Faucon, Adrien Lascialfari, Alessandro Ishow, Eléna Orlando, Tomas Fresnais, Jérôme |
| Description | Country affiliation: France Author Affiliation: Faucon A ( CEISAM-UMR CNRS 6230, Université de Nantes, 2 rue de la Houssinière, 44322 Nantes, France.); Benhelli-Mokrani H ( UFIP-UMR CNRS 6204, Université de Nantes, 2 rue de la Houssinière, 44322 Nantes, France.); Fleury F ( UFIP-UMR CNRS 6204, Université de Nantes, 2 rue de la Houssinière, 44322 Nantes, France.); Dubreil L ( Pan Ther-UMR 703, INRA-ONIRIS, Atlanpole-Chanterie, 44307 Nantes, France.); Hulin P ( INSERM UMS 016-UMS CNRS 3556, 8 quai Moncousu, 44007 Nantes, France.); Nedellec S ( INSERM UMS 016-UMS CNRS 3556, 8 quai Moncousu, 44007 Nantes, France.); Doussineau T ( Institut Lumière Matière-UMR CNRS 5306, Université de Lyon, 69622 Villeurbanne cedex, France.); Antoine R ( Institut Lumière Matière-UMR CNRS 5306, Université de Lyon, 69622 Villeurbanne cedex, France.); Orlando T ( Department of Physics, Università di Pavia, via Bassi, 27100 Pavia, Italy.); Lascialfari A ( Department of Physics, Università di Pavia, via Bassi, 27100 Pavia, Italy); Fresnais J ( Sorbonne Universités, UPMC Univ. Paris 06, CNRS, Laboratoire PHENIX, 4 place Jussieu, 75005 Paris, France.); Lartigue L ( CEISAM-UMR CNRS 6230, Université de Nantes, 2 rue de la Houssinière, 44322 Nantes, France.); Ishow E ( CEISAM-UMR CNRS 6230, Université de Nantes, 2 rue de la Houssinière, 44322 Nantes, France. Electronic address: elena.ishow@univ-nantes.fr.) |
| Abstract | High-density nanoarchitectures, endowed with simultaneous fluorescence and contrast properties for MRI and TEM imaging, have been obtained using a simple self-assembling strategy based on supramolecular interactions between non-doped fluorescent organic nanoparticles (FON) and superparamagnetic nanoparticles. In this way, a high-payload core-shell structure FON@mag has been obtained, protecting the hydrophobic fluorophores from the surroundings as well as from emission quenching by the shell of magnetic nanoparticles. Compared to isolated nanoparticles, maghemite nanoparticles self-assembled as an external shell create large inhomogeneous magnetic field, which causes enhanced transverse relaxivity and exacerbated MRI contrast. The magnetic load of the resulting nanoassemblies is evaluated using magnetic sedimentation and more originally electrospray mass spectrometry. The role of the stabilizing agents (citrate versus polyacrylate anions) revealed to be crucial regarding the cohesion of the resulting high-performance magneto-fluorescent nanoassemblies, which questions their use after cell internalization as nanocarriers or imaging agents for reliable correlative light and electron microcopy. |
| ISSN | 00219797 |
| Journal | Journal of Colloid and Interface Science |
| Volume Number | 479 |
| e-ISSN | 10957103 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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