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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Casadei, Maria Antonietta Jungnickel, Christian Paolicelli, Patrizia Cesa, Stefania Krasodomska, Olga |
| Description | Country affiliation: Poland Author Affiliation: Krasodomska O ( Department of Colloid and Lipid Science, Faculty of Chemistry, Gdansk University of Technology, ul. Narutowicza 11/12, 80-233 Gdansk, Poland.); Paolicelli P ( Department of Drug Chemistry and Technologies, 'Sapienza' University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy.); Cesa S ( Department of Drug Chemistry and Technologies, 'Sapienza' University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy.); Casadei MA ( Department of Drug Chemistry and Technologies, 'Sapienza' University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy.); Jungnickel C ( Department of Colloid and Lipid Science, Faculty of Chemistry, Gdansk University of Technology, ul. Narutowicza 11/12, 80-233 Gdansk, Poland. Electronic address: christian.jungnickel@pg.gda.pl.) |
| Abstract | In this paper, we focused on the development of nanostructured lipid carriers (NLCs) for dermal application. The NLC matrix was designed as a protective reservoir of biological active compounds that naturally occur in domestic fruit seed oils. Over the years, emulsions, as a popular physicochemical form of personal care products, were refined in order to obtain the best possible penetration into the skin of any bioactive compound introduced in the formulation, such as polyunsaturated fatty acids (PUFAs). In fact, the bioactive components are useful only if they are able to penetrate the skin unchanged. Therefore, an alternate way to deliver naturally occurring PUFAs is needed. NLCs present a novel delivery and protection system for the PUFAs. The cold pressed fruit seed oils obtained from waste material were used in this paper: blackcurrant, blackberry, raspberry, strawberry and plum. Thermodynamic (DSC) and structural techniques ((1)H NMR) were applied in order to characterize the obtained systems in terms of seed oil incorporation into the NLC, and oxidative stability tests were used to confirm the protective quality of the systems. During the formulation optimization process the most stable nanosuspension with the best seed oil incorporation was a mixture of 4% nonionic emulsifiers, 88% water and 6% lipids with a ratio of 6:2, wax:oil. The oxidative stability tests showed that the NLC was an effective method of protection of the PUFAs. |
| ISSN | 00219797 |
| Journal | Journal of Colloid and Interface Science |
| Volume Number | 479 |
| e-ISSN | 10957103 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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