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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jurado-Sánchez, Beatriz Gallego, Mercedes Ballesteros, Evaristo |
| Description | Country affiliation: Spain Author Affiliation: Jurado-Sánchez B ( Department of Analytical Chemistry, Campus of Rabanales, University of Córdoba, E-14071 Córdoba, Spain.) |
| Abstract | The detection of N-nitrosamines (NAms) in water supplies is an environmental and public health issue because many NAms are classified as probable human carcinogens. Non-aromatic (aliphatic and cyclic) NAms are more toxic than aromatic ones as their maximum admissible concentration is limited in drinking water (20-2000ngL(-1)). From that premise, a simple and novel method to discriminate between both fractions of NAms according to their toxicity was proposed. An automatic solid-phase extraction unit containing two sequential sorbent columns was constructed. A sample volume of 25mL was passed through a C(60) fullerene column in which only the aromatic fraction was retained, and the effluent was then passed through a Merck LiChrolut EN column where the non-aromatic fraction was retained. Following elution of the non-aromatic NAms with 150microL of ethyl acetate-acetonitrile (9:1), 1microL of the extract was injected into a GC/MS. A comparative study of C(60) and C(70) fullerenes and nanotubes revealed C(60) fullerene to be the best choice to selectively retain the aromatic fraction. The method exhibits a linear range of 15-20,000ngL(-1); limits of detection of 4-15ngL(-1); and an RSD of approximately 5%. Recoveries throughout the whole method were between 95% and 102% for six non-aromatic NAms spiked into several types of waters. Our study demonstrates that a simple and fast SPE system (10min per sample) with a customary GC-MS instrument permits the quantification of these amines in complex matrices with considerable sensitivity and selectivity. |
| ISSN | 00219673 |
| Issue Number | 7 |
| Volume Number | 1216 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-02-13 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Chromatography, Gas Methods Fullerenes Chemistry Nitrosamines Isolation & Purification Solid Phase Extraction Adsorption Equipment Design Reproducibility Of Results Sensitivity And Specificity Water Water Pollutants, Chemical Analysis Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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