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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wintersteiger, Reinhold Leis, Hans J. Donnarumma, Fabrizio Ortner, Astrid Lazarus, Regina Braml, Barbara Windischhofer, Werner |
| Description | Country affiliation: Austria Author Affiliation: Leis HJ ( University Children's Hospital, Research Unit of Osteology and Analytical Mass Spectrometry, Medical University Graz, Graz, Austria. hans.leis@medunigraz.at) |
| Abstract | Targeted anti-cancer combination therapy with infusion of N-acetyl-L-methionine (NALM) and N-acetyl-L-selenomethionine (NASeLM) shows promising results in cancer treatment. Selenium has been recognised as a valuable additive in cancer therapeutics due to its ability to minimise side effects of chemotherapy and its role in cancer prevention and therapy. Due to the promising results of this new therapeutic approach evaluation of pharmacokinetic data for NALM and NASeLM is of ultimate importance. We have therefore elaborated a method for the quantitative measurement of these compounds in human plasma based on GC-negative ion chemical ionisation-MS. The derivatisation sequence elaborated can be regarded as a novel strategy for the chemical modification of delicate sulphur- and selenium-containing compounds, and underlines the enhanced reactivity of selenium-analogues of sulphur-containing amino acids. The target compounds were extracted from plasma with ethyl acetate and converted to the S/Se-pentafluorobenzyl-homocysteine pentafluorobenzyl ester derivative. Reaction conditions were optimised for derivative yield. Calibration graphs were established in the range of 2.938-481.105 ng/0.5 mL plasma (NALM) and 0.233-59.543 ng/0.5 mL plasma (NASeLM). Accuracy, precision and stability data were elaborated. The method was applied to pharmacokinetic profiling of the compounds after infusion into human volunteers. |
| ISSN | 00219673 |
| Volume Number | 1242 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Fluorobenzenes Chemistry Gas Chromatography-mass Spectrometry Methods Methionine Analogs & Derivatives Selenomethionine Acetylation Drug Stability Humans Blood Regression Analysis Reproducibility Of Results Journal Article Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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