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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yilmaz, Bilal Erdem, Ali Fuat |
| Description | Country affiliation: Turkey Author Affiliation: Yilmaz B ( Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum 25240, Turkey yilmazb@atauni.edu.tr.); Erdem AF ( Department of Anesthesiology and Reanimation, Faculty of Medicine, Sakarya University, Sakarya 54187, Turkey.) |
| Abstract | A sensitive and efficient method was developed for determination of tramadol and its metabolite (O-desmethyltramadol) in human urine by gas chromatography-mass spectrometry. Tramadol, O-desmethyltramadol and medazepam (internal standard) were extracted from human urine with a mixture of ethylacetate and diethylether mixture (1 : 1, v/v) at basic pH with liquid-liquid extraction. The calibration curves were linear (r = 0.99) over tramadol and O-desmethyltramadol concentrations ranging from 10 to 200 ng/mL and 7.5 to 300 ng/mL, respectively. The method had an accuracy of >95% and intra- and interday precision (relative standard deviation %) of ≤4.93 and ≤4.62% for tramadol and O-desmethyltramadol, respectively. The extraction recoveries were found to be 94.1 ± 2.91 and 96.3 ± 3.46% for tramadol and O-desmethyltramadol, respectively. The limit of quantification using 0.5 mL human urine was 10 ng/mL for tramadol and 7.5 ng/mL for O-desmethyltramadol. After oral administration of 100 mg of tramadol hydrochloride to a patient, the urinary excretion was monitored during 24 h. About 15% of the dose was excreted as unchanged tramadol. |
| File Format | HTM / HTML |
| ISSN | 00219665 |
| e-ISSN | 1945239X |
| Journal | Journal of Chromatographic Science |
| Issue Number | 7 |
| Volume Number | 53 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2015-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Analytical Chemistry Analgesics, Opioid Urine Gas Chromatography-mass Spectrometry Tramadol Analogs & Derivatives Limit Of Detection Liquid-liquid Extraction Reproducibility Of Results Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Analytical Chemistry |
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