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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Stolk, Jan Viglio, Simona Luisetti, Maurizio Tinelli, Carmine Ferrari, Fabio Fumagalli, Marco Piccinini, Paolo Iadarola, Paolo |
| Description | Country affiliation: Italy Author Affiliation: Ferrari F ( LabAnalysis Inc., Casanova Lonati, Pavia, Italy.) |
| Abstract | Evidences accumulated over the past years that desmosines could be attractive indicators of elastic fibre degradation in Chronic Obstructive Pulmonary Disease have raised substantial interest with the development of reliable assays to measure their concentration in body fluids. It is a firm belief of researchers working in this field that accurate assessment of desmosine concentration would improve the understanding of elastin metabolism disorders and allow these cross-links to become a useful tool in the diagnosis and clinical management of these diseases. From among the variety of techniques available on the market, HPLC; CE and LC-MS have proved to be successful tools for measuring desmosines in biological fluids. However, differences in the analytical performance of methods may hinder the comparability of data, thus limiting the analytical strength and clinical utility of methods themselves. To address the relative contribution of different factors to the exact quantification of desmosines, the full potential of MEKC-LIF and LC-MS, the two systems that better than others offer more selective and sensitive detection for desmosine analysis, was studied on 56 urine samples. The results of this systematic comparative study underline the significant benefits of LC-MS over MEKC-LIF in terms of precision and sensitivity. Nevertheless, MEKC-LIF could be an attractive alternative in routine laboratories lacking the LC-MS instrumentation and skills to run these methods. |
| ISSN | 00219673 |
| Volume Number | 1266 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-30 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Chromatography, Liquid Methods Chromatography, Micellar Electrokinetic Capillary Desmosine Urine Pulmonary Disease, Chronic Obstructive Tandem Mass Spectrometry Case-control Studies Instrumentation Humans Micelles Reproducibility Of Results Sensitivity And Specificity Comparative Study Journal Article Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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