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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ramírez Fernández, María del Mar Wille, Sarah M. R. Di Fazio, Vincent Gosselin, Matthias Samyn, Nele |
| Description | Country affiliation: Belgium Author Affiliation: Ramírez Fernández Mdel M ( Federal Public Service Justice, National Institute of Criminalistics and Criminology, Laboratory of Toxicology, Brussels, Belgium. marmixoscity@gmail.com) |
| Abstract | A simple, rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry method was developed and fully validated for the quantitative determination of seven amphetamines and metabolites in urine. The method was validated for selectivity, linearity, LOQ, LOD, imprecision, bias, analyte and processed sample stability, matrix effect, recovery, carryover and dilution integrity. A classic liquid-liquid extraction with ethyl acetate was used as sample preparation procedure. The compounds were separated on an Acquity UPLC HSS C18 column in 6.8 min. The linear dynamic range was established from 25 to 500 ng/mL. The limit of quantification was fixed to the lowest calibrator level and the limit of detection ranged from 0.125 to 2.5 ng/mL. The method presented an excellent intra- and inter-assay imprecision and bias (<10.7%) at each measured concentration of two external quality controls (QC) and three 'in house' QC. No matrix effects were observed and good recoveries (>70%) were obtained for all the compounds. No carryover was observed after the analysis of high concentrated samples (8000 ng/mL). The method was subsequently applied to authentic samples. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Issue Number | 19 |
| Volume Number | 878 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Amphetamines Chromatography, High Pressure Liquid Methods Tandem Mass Spectrometry Metabolism Urine Drug Stability Humans Reproducibility Of Results Sensitivity And Specificity Solid Phase Extraction Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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