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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bamba, Takeshi Taguchi, Kaori Fukusaki, Eiichiro |
| Description | Country affiliation: United States Author Affiliation: Taguchi K ( Waters Corporation, 34 Maple Street, Milford, MA 01757, USA.) |
| Abstract | A number of analysis methods for bile acids using LC-MS and GC-MS have been reported. However, there is no reported method for the simultaneous analysis of bile acids using supercritical fluid chromatography (SFC). In this study, we have successfully developed a rapid method using SFC coupled to electrospray ionization tandem mass spectrometry (ESI-MS/MS) for comprehensive bile acid profiling. 25 bile acids including glycine and taurine conjugates were analyzed simultaneously within 13min. The method was applied to rat serum samples, 24 of the bile acids were quantified without any solid-phase extraction and complicated sample preparation. This study not only reports simultaneous analysis of bile acids including conjugates but also indicates the method is applicable to a biological sample. This is the first report on the simultaneous analysis of bile acids using SFC/MS. The developed method will be an alternative to existing analysis methodology for studies on the bile acid metabolism in the medical and pharmaceutical fields. |
| ISSN | 00219673 |
| Volume Number | 1299 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-19 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Bile Acids And Salts Analysis Chromatography, Supercritical Fluid Methods Gas Chromatography-mass Spectrometry Tandem Mass Spectrometry Animals Blood Rats Reproducibility Of Results Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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