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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Patel, Darshan C. Gao, Hongyin Breitbach, Zachary S. Li, Gongqiang Armstrong, Daniel W. Keene, Craig Kürti, László Lim, Yeeun Woods, Ross M. |
| Description | Country affiliation: United States Author Affiliation: Woods RM ( The University of Texas at Arlington, 700 Planetarium Place, Arlington, TX 76019, USA.); Patel DC ( The University of Texas at Arlington, 700 Planetarium Place, Arlington, TX 76019, USA.); Lim Y ( The University of Texas at Arlington, 700 Planetarium Place, Arlington, TX 76019, USA.); Breitbach ZS ( The University of Texas at Arlington, 700 Planetarium Place, Arlington, TX 76019, USA.); Gao H ( Division of Chemistry, Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.); Keene C ( Division of Chemistry, Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.); Li G ( Division of Chemistry, Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.); Kürti L ( Division of Chemistry, Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.); Armstrong DW ( The University of Texas at Arlington, 700 Planetarium Place, Arlington, TX 76019, USA) |
| Abstract | Normal phase chiral HPLC methods are presented for the enantiomeric separation of 30 biaryl atropisomers including 18 new compounds recently produced via a novel synthetic approach. Three new cyclofructan based chiral stationary phases were evaluated. Separations were achieved for all but six analytes and the LARIHC™ CF6-P alone provided 15 baseline separations. Effects of polar modifiers and temperature effects also were studied. Apparent thermodynamic parameters were determined by van't Hoff plots. Preparative scale methods were developed and employed resulting in the first ever isolation of these novel atropisomers in their pure enantiomeric form. Insights into the mechanism of retention and chiral discrimination are presented. |
| ISSN | 00219673 |
| e-ISSN | 18733778 |
| DOI | 10.1016/j.chroma.2014.04.080 |
| Journal | Journal of Chromatography A |
| Volume Number | 1357 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-08-29 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Chromatography, High Pressure Liquid Fructans Chemistry Organic Chemicals Isolation & Purification Instrumentation Stereoisomerism Thermodynamics Evaluation Studies Research Support, N.i.h., Extramural Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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