NDLI: Enantiomeric resolution of melatonin ligands receptors by liquid chromatography on amylose chiral stationary phases

Content Provider	Springer Nature Link
Author	Vaccher, C. Fourmaintraux, E. Belloli, E. Vaccher, M. p. Bonte, J. P.
Copyright Year	1998
Abstract	Analytical HPLC methods using derivatized amylose chiral stationary phases were developed for the resolution of enantiomers of methoxy an ethyl tetrahydronaphthalenic derivatives, new agonist and antagonist ligands for melatonin receptors. Separation was by normal phase methodology with a mobile phase ofn-hexane-alcohol (methanol, ethanol, 1-propanol or 2-propanol) in various proportions, and a silica-based, amylose tris-(S)-1-phenylethylcarbamate (Chiralpak AS), or tris-3,5-dimethylphenylcarbamate (Chiralpak AD). The mobile phase and the chiral stationary phase were optimized for best resolution. The effects of concentration of alcohol, various aliphatic alcohols in the mobile phase were studied. The effects of substitution were analysed. Baseline separation (Rs>1.5) was easily obtained in man cases.
Starting Page	790
Ending Page	796
Page Count	7
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	48
Issue Number	11-12
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	1998-01-01
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromatography Chiral-enantiomeric separation Amylose-based chiral phases Melatonin analogues Tetrahydronaphthalenes Analytical Chemistry Organic Chemistry Pharmacy Biochemistry Plant Sciences Measurement Science, Instrumentation
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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