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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rajendran, Arvind Li, Geng Dai, Yun |
| Description | Country affiliation: Singapore Author Affiliation: Dai Y ( School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore.); Li G ( School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore.); Rajendran A ( School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore) |
| Abstract | Preparative separations in supercritical fluid chromatography (SFC) involve the injection of large volumes of the solute. In SFC, the mobile phase is typically high pressure CO2+modifier and the solute to be injected is usually dissolved in the modifier. Two-types of injection methods, modifier-stream and mixed-stream, are common in commercial preparative SFC systems. In modifier-stream injection, the injection is made in the modifier stream which is later mixed with the CO2 stream, while in the mixed-stream injection, the injection is made in a mixed CO2+modifier stream. In this work a systematic experimental and modelling study of the two techniques is reported using single-enantiomers of flurbiprofen on Chiralpak AD-H with CO2+methanol as the mobile phase. While modifier-stream injection shows non-distorted peaks, mixed-stream injection results in severe peak-distortion. By comparing the modelling and experimental results, it is shown that the modifier 'plug' introduced in the mixed-stream injection is the primary cause of the peak distortions. The experimental results also point to the possible existence of viscous fingering which contributes to further peak distortion. |
| ISSN | 00219673 |
| Volume Number | 1392 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Chromatography, Supercritical Fluid Methods Amylose Analogs & Derivatives Carbon Dioxide Flurbiprofen Analysis Methanol Phenylcarbamates Pressure Stereoisomerism Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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