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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Song, Hui-Peng Long, Fang Xu, Zhi-Meng Li, Ping Wu, Si-Qi Yang, Hua Qi, Lian-Wen Jiang, Li-Feng Zeng, Hao Liu, Ke |
| Description | Country affiliation: China Author Affiliation: Song HP ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.); Wu SQ ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.); Qi LW ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.); Long F ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.); Jiang LF ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.); Liu K ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.); Zeng H ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.); Xu ZM ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.); Li P ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: liping2004@126.com.); Yang H ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: 104yang104@163.com.) |
| Abstract | Screening and deciphering active natural products of herbal medicines are of great importance for modern drug discovery. In this study, a novel strategy was proposed to rapidly filter ineffective compounds and target the most potential leads. The aim is to answer the key question of what components are responsible for the holistic bioactivity of an herbal product. To support the strategy, the pharmacophore-guided knockout/knockin chromatography was established for the first time. The greatest advantage of this method is that any interesting components could be automatically fished or knocked out. The method validation shows that the herbal extract was accurately reconstructed according to the experimental design. By combining with bioactivity assays, we demonstrated that 'functional compound combination (FCC)', which is the core and indispensable effective part, could be discovered from an herbal medicine and suitable as marker compounds for quality control. The applicable objects of the strategy include single herbs, herbal formulas and commercially herbal preparations. As an illustrative case study, the strategy was successfully applied to simultaneously determine active leads and the FCC in Dan-Qi formula which shows excellent free radical scavenging activity. The potential mechanisms of compounds in Dan-Qi formula reacting with three different free radicals were systematically reported for the first time. This strategy was expected to unveil the mystery of herbal medicines and inspire a natural product-based drug discovery. |
| ISSN | 00219673 |
| Journal | Journal of Chromatography A |
| Volume Number | 1456 |
| e-ISSN | 18733778 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-07-22 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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