NDLI: Intraocular biomarker identification in uveitis associated with juvenile idiopathic arthritis.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2013 Volume: 54 Issue: 14

Year: 2013 Volume: 54 Issue: 13

Year: 2013 Volume: 54 Issue: 12

Year: 2013 Volume: 54 Issue: 11

Year: 2013 Volume: 54 Issue: 10

Year: 2013 Volume: 54 Issue: 9

Year: 2013 Volume: 54 Issue: 8

Year: 2013 Volume: 54 Issue: 7

Year: 2013 Volume: 54 Issue: 6

Year: 2013 Volume: 54 Issue: 5

Screening of RB1 alterations in Brazilian patients with retinoblastoma and relatives with retinoma: phenotypic and genotypic associations.

Mature dendritic cell suppression by IL-1 receptor antagonist on retinal pigment epithelium cells.

Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration.

Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma.

Wavelength optimization in femtosecond laser corneal surgery.

Factors affecting corneoscleral topography.

Dual cognitive task affects reaching and grasping behavior in subjects with macular disorders.

Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma.

Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy: in vivo and in vitro.

Aß-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD.

Lectin microarray profiling and relative quantification of glycome associated with proteins of neonatal wt and rd1 mice retinae.

Two-photon microscopy and fluorescence lifetime imaging of retinal pigment epithelial cells under oxidative stress.

Targeted expression of anoctamin calcium-activated chloride channels in rod photoreceptor terminals of the rodent retina.

Modified monovision with spherical aberration to improve presbyopic through-focus visual performance.

The relationship between cup-to-disc ratio and estimated number of retinal ganglion cells.

Vertical vergence adaptation produces an objective vertical deviation that changes with head tilt.

Factors predicting the ocular surface response to desiccating environmental stress.

ON and OFF electroretinography and contrast sensitivity in Duchenne muscular dystrophy.

In vivo corneal oxygen uptake during soft-contact-lens wear.

Choroidal oximetry with a noninvasive spectrophotometric oximeter.

A fish scale-derived collagen matrix as artificial cornea in rats: properties and potential.

Coherent anti-stokes Raman scattering (CARS) microscopy: a novel technique for imaging the retina.

Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the P38 MAP kinase pathway.

A naturally occurring mouse model of achromatopsia: characterization of the mutation in cone transducin and subsequent retinal phenotype.

lukSF-PV in Staphylococcus aureus keratitis isolates and association with clinical outcome.

Sunitinib inhibits inflammatory corneal lymphangiogenesis.

Perivascular cells with pericyte characteristics are involved in ATP- and PGE(2)-induced relaxation of porcine retinal arterioles in vitro.

Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation.

Observation of posterior precortical vitreous pocket using swept-source optical coherence tomography.

Collagen cross-linking using rose bengal and green light to increase corneal stiffness.

Does acute primary angle-closure cause an increased choroidal thickness?

Reduction in blood glutathione levels occurs similarly in patients with primary-open angle or normal tension glaucoma.

Abnormal corneal endothelial maturation in collagen XII and XIV null mice.

Localized reticular pseudodrusen and their topographic relation to choroidal watershed zones and changes in choroidal volumes.

Longitudinal changes in anterior segment parameters after laser peripheral iridotomy assessed by anterior segment optical coherence tomography.

Detecting glaucoma with visual fields derived from frequency-domain optical coherence tomography.

Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma.

Dexamethasone intravitreal implant for treatment of patients with recalcitrant macular edema resulting from Irvine-Gass syndrome.

Copy number variation at chromosome 5q21.2 is associated with intraocular pressure.

SIK2 is involved in the negative modulation of insulin-dependent muller cell survival and implicated in hyperglycemia-induced cell death.

Increased fragility, impaired differentiation, and acceleration of migration of corneal epithelium of epiplakin-null mice.

Wavelength dependence of the ocular straylight.

Disruption of the centrifugal visual system inhibits early eye growth in chicks.

A functional polymorphism at the FGF10 gene is associated with extreme myopia.

Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix.

Cost-effectiveness of treating normal tension glaucoma.

Changes in choroidal thickness in relation to the severity of retinopathy and macular edema in type 2 diabetic patients.

Preclinical study of Ublituximab, a Glycoengineered anti-human CD20 antibody, in murine models of primary cerebral and intraocular B-cell lymphomas.

Retinoic acid inhibits CD25+ dendritic cell expansion and Î³Î´ T-cell activation in experimental autoimmune uveitis.

Individual A-scan signal normalization between two spectral domain optical coherence tomography devices.

Comparison of low-abundance biomarker levels in capillary-collected nonstimulated tears and washout tears of aqueous-deficient and normal patients.

A wide-field suprachoroidal retinal prosthesis is stable and well tolerated following chronic implantation.

JAK1, but not JAK2 and STAT3, confers susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.

TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway.

The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells.

Heritability of myopia and ocular biometrics in Koreans: the healthy twin study.

Sodium hyaluronate decreases ocular surface toxicity induced by benzalkonium chloride-preserved latanoprost: an in vivo study.

Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury.

Structural and functional effects of hemiretinal endodiathermy axotomy in cynomolgus macaques.

Static and flicker perimetry in age-related macular degeneration.

Adaptive optics imaging of geographic atrophy.

Intraocular biomarker identification in uveitis associated with juvenile idiopathic arthritis.

A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy.

The continuum of detection and awareness of visual stimuli within the blindfield: from blindsight to the sighted-sight.

The relationship between cord blood cytokine levels and perinatal factors and retinopathy of prematurity: a gestational age-matched case-control study.

Longitudinal analysis of progression in glaucoma using spectral-domain optical coherence tomography.

Dry eye syndrome, posttraumatic stress disorder, and depression in an older male veteran population.

Noninvasive investigation of deep vascular pathologies of exudative macular diseases by high-penetration optical coherence angiography.

Human photoreceptor outer segments shorten during light adaptation.

Influence of macular pigment on retinal straylight in healthy eyes.

Comparison of the optical image quality in the periphery of phakic and pseudophakic eyes.

Characteristics of on-road driving performance of persons with central vision loss who use bioptic telescopes.

Choroidal thickness in childhood.

Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians.

A magnetic bead-based method for mouse trabecular meshwork cell isolation.

Intravitreal injection of ranibizumab for recovery of macular function in eyes with subfoveal polypoidal choroidal vasculopathy.

Binocular vision and eye movement disorders in older adults.

Overexpression of SIRT1 promotes high glucose-attenuated corneal epithelial wound healing via p53 regulation of the IGFBP3/IGF-1R/AKT pathway.

Association between baseline angle width and induced angle opening following prophylactic laser peripheral iridotomy.

Aquaporin expression and function in human pluripotent stem cell-derived retinal pigmented epithelial cells.

Visual deprivation and foveation characteristics both underlie visual acuity deficits in idiopathic infantile nystagmus.

Author response: macular migration toward the optic disc after inner limiting membrane peeling for diabetic macular edema.

Validating retinal fundus image analysis algorithms: issues and a proposal.

Year: 2013 Volume: 54 Issue: 4

Year: 2013 Volume: 54 Issue: 3

Year: 2013 Volume: 54 Issue: 2

Year: 2013 Volume: 54 Issue: 1

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Intraocular biomarker identification in uveitis associated with juvenile idiopathic arthritis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Coulton, Gary R. Schellekens, Peter A. W. J. F. Dekkers, Jojanneke Rothova, Aniki de Groot-Mijnes, Jolanda D. F. Kalinina Ayuso, Viera Van Loon, Anton M. de Visser, Lenneke de Boer, Joke H. Byers, Helen L.
Description	Country affiliation: Netherlands Author Affiliation: Kalinina Ayuso V ( Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands. v.kalininaayuso@umcutrecht.nl)
Abstract	PURPOSE: To investigate the presence of biomarkers in aqueous humor (AH) from patients with uveitis associated with juvenile idiopathic arthritis (JIA). METHODS: AH (N = 73) AND SERUM (N = 105) SAMPLES FROM 116 CHILDREN WERE ANALYZED USING SURFACE ENHANCED LASER DESORPTION/IONIZATION TIME OF FLIGHT MASS SPECTROMETRY (SELDI-TOF MS). THE SAMPLES WERE DIVIDED INTO THE FOLLOWING GROUPS: JIA, silent chronic anterior uveitis (AU), other uveitis entities, and noninflammatory controls. Statistical biomarker identification was performed using the SELDI-ToF Biomarker Analysis Cluster Wizard followed by multivariate statistical analysis. Biochemical identification of biomarkers was performed by polyacrylamide gel protein separation, followed by liquid chromatography tandem mass spectrometry. ELISA was performed in a number of AH samples representing all four study groups. RESULTS: In the JIA group, one AH protein peak at mass/charge (m/z) 13,762 had qualitative and quantitative differences in expression compared with the other uveitis entities and the controls, but not to the group of silent chronic AU. Its quantitative expression in AH of patients with JIA and other silent chronic AU was positively associated with uveitis activity. The protein at m/z 13,762 in AH was identified as transthyretin (TTR). The TTR concentration in AH differed significantly between the study groups (P = 0.006) with considerably higher TTR concentrations in JIA and silent chronic AU samples positive for m/z 13,762 than those of the other uveitis and control groups. CONCLUSIONS: TTR is a potential intraocular biomarker of JIA- associated uveitis. Its role in the pathogenesis of silent chronic AU with and without arthritis needs further investigation.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	5
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aqueous Humor Metabolism Arthritis, Juvenile Complications Proteomics Uveitis Adolescent Biological Markers Cataract Child, Preschool Glaucoma Infant Spectrometry, Mass, Matrix-assisted Laser Desorption-ionization Diagnosis Etiology Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in