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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chan, Yau Kei Shum, Ho Cheung Man, Ping Kwan Wong, Chun Yu Wong, David Sy, Kwun Hei Samuel |
| Description | Country affiliation: Hong Kong Author Affiliation: Chan YK ( Department of Mechanical Engineering, Faculty of Engineering, University of Hong Kong, Hong Kong 2Department of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.); Sy KH ( Department of Mechanical Engineering, Faculty of Engineering, University of Hong Kong, Hong Kong.); Wong CY ( Department of Mechanical Engineering, Faculty of Engineering, University of Hong Kong, Hong Kong.); Man PK ( Department of Mechanical Engineering, Faculty of Engineering, University of Hong Kong, Hong Kong.); Wong D ( Department of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.); Shum HC ( Department of Mechanical Engineering, Faculty of Engineering, University of Hong Kong, Hong Kong 3University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, Guangdong, China.) |
| Abstract | PURPOSE: There is a lack of a standardized methodology or a physiologically realistic in vitro model to investigate silicone oil (SO) emulsification. In this study, we replicated the SO-aqueous interface within a microfluidic chip to study the formation of SO emulsion droplets in the eye cavity. METHODS: A chip made of poly(methylmethacrylate) was used to represent a cross-section of the posterior eye chamber. A retinal ganglion cell line was coated on the inner surface of the chamber to mimic the surface property of the retina. Silicone oil of different viscosities were tested. The SO-aqueous interface was created inside the chip, which, in turn, was affixed to a stepper-motor-driven platform and subjected to simulated saccadic eye movement for four days. Optical microscopy was used to quantify the count and size of SO emulsified droplets. RESULTS: Among SO of different viscosities, SO 5 centistokes (cSt) emulsifies readily, and a high number of droplets formed inside the chip. Silicone oil 100 cSt led to fewer droplets than 5 cSt, but the droplet count was still significantly higher than other SO of higher viscosities. There were no significant differences in the number of droplets among SO with viscosities of 500, 1000, and 5000 cSt. In all SOs tested, the number of droplets increased, whereas their size decreased with longer duration of simulated saccades. CONCLUSIONS: The study platform allows quantification of the number and size of emulsified SO droplets in situ. More importantly, this platform demonstrates the potential of microtechnology for constructing a more physiologically realistic in vitro eye model. Eye-on-a-chip technology presents exciting opportunities to study emulsification and potentially other phenomena in the human eye. |
| ISSN | 01460404 |
| e-ISSN | 15525783 |
| Journal | Investigative Opthalmology & Visual Science |
| Issue Number | 5 |
| Volume Number | 56 |
| Language | English |
| Publisher | Association for Research in Vision and Ophthalmology |
| Publisher Date | 2015-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Saccades Physiology Silicone Oils Chemistry Viscosity Cell Line Emulsions Endotamponade Models, Anatomic Models, Biological Polymethacrylic Acids Retinal Ganglion Cells Surface Properties Research Support, Non-u.s. Gov't Discipline Ophthalmology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
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