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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kieselbach, Gerhard F. Bechrakis, Nikolaos E. Stattin, Martin Zehetner, Claus Kirchmair, Rudolf Ulmer, Hanno Kralinger, Martina T. |
| Description | Country affiliation: Austria Author Affiliation: Zehetner C ( Department of Ophthalmology Medical University Innsbruck, Innsbruck, Austria.); Bechrakis NE ( Department of Ophthalmology Medical University Innsbruck, Innsbruck, Austria.); Stattin M ( Department of Ophthalmology Medical University Innsbruck, Innsbruck, Austria.); Kirchmair R ( Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.); Ulmer H ( Department of Medical Statistics, Informatics and Health Economics, Medical University Innsbruck, Innsbruck, Austria.); Kralinger MT ( Department of Ophthalmology Medical University Innsbruck, Innsbruck, Austria.); Kieselbach GF ( Department of Ophthalmology Medical University Innsbruck, Innsbruck, Austria.) |
| Abstract | PURPOSE: Placental growth factor (PlGF) has been implicated as a contributor to resistance against anti-VEGF therapy. The purpose of the present study was to analyze the systemic levels of PlGF, VEGF-A, and VEGF-B in patients with neovascular age-related macular degeneration (AMD) after treatment with aflibercept, ranibizumab, or bevacizumab. METHODS: Totals of 19 patients were treated with intravitreal aflibercept, 19 with ranibizumab, and 18 with bevacizumab. The cytokine levels were measured by ELISA just before the injection, and 7 days and 1 month thereafter. Age- and sex-matched participants (n = 22) served as controls. RESULTS: The median PlGF plasma concentration at baseline was <12.0 pg/mL in the control group as well as in all three anti-VEGF treatment cohorts. After intravitreal aflibercept injection, a significant upregulation of systemic PlGF could be observed in all treated patients (38.0 [31.0-44.0] pg/mL after 1 week [P < 0.001] and 16.0 [0.0-19.0] pg/mL [P = 0.005] after 4 weeks). No significant effects on plasma PlGF concentrations could be detected in those treated with ranibizumab and bevacizumab. The systemic VEGF-A levels were significantly reduced 1 and 4 weeks after intravitreal aflibercept (P < 0.001, P < 0.001) and bevacizumab (P < 0.001, P < 0.01) injections. No significant effects on plasma cytokine concentrations could be observed in the ranibizumab cohort. No significant effects on systemic VEGF-B could be observed in any of the treatment groups. CONCLUSIONS: In this study, we report a significant systemic upregulation of the proangiogenic cytokine PlGF after intravitreal administration of aflibercept. This might represent a counter-regulatory response to antiangiogenic therapy. |
| ISSN | 01460404 |
| e-ISSN | 15525783 |
| Journal | Investigative Opthalmology & Visual Science |
| Issue Number | 5 |
| Volume Number | 56 |
| Language | English |
| Publisher | Association for Research in Vision and Ophthalmology |
| Publisher Date | 2015-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Angiogenesis Inhibitors Administration & Dosage Macular Degeneration Drug Therapy Pregnancy Proteins Blood Receptors, Vascular Endothelial Growth Factor Recombinant Fusion Proteins Antibodies, Monoclonal, Humanized Bevacizumab Cytokines Enzyme-linked Immunosorbent Assay Intravitreal Injections Prospective Studies Ranibizumab Vascular Endothelial Growth Factor A Antagonists & Inhibitors Visual Acuity Observational Study Randomized Controlled Trial Discipline Ophthalmology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
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