NDLI: A novel COL7A1 mutation in a Korean patient with Hallopeau-Siemens recessive dystrophic epidermolysis bullosa.

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A novel COL7A1 mutation in a Korean patient with Hallopeau-Siemens recessive dystrophic epidermolysis bullosa.

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A novel COL7A1 mutation in a Korean patient with Hallopeau-Siemens recessive dystrophic epidermolysis bullosa.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, M. Chae, H. Park, Y. M. Park, I. Y. Park, J. Kim, Y. Shin, J. C.
Spatial Coverage	Republic of Korea
Description	Author Affiliation: Park J ( Department of Laboratory Medicine, College of Medicine, Catholic University of Korea, Seoul, Korea.)
Abstract	Dystrophic epidermolysis bullosa (DEB) is an inherited skin fragility disorder that presents various clinical manifestations. DEB is characterized by separation of sublamina densa tissue and abnormalities in the anchoring fibrils that result from mutations in COL7A1 and subsequent defects in type VII collagen. A 16-month-old boy was diagnosed with Hallopeau-Siemens recessive DEB on the basis of typical skin lesions composed of multiple blisters with moderately healed erosions, scarring on trauma-exposed body sites, including hands and feet, pseudosyndactyly and flexion contractures of the toes, and severely dystrophic nails on the right hand. Genomic DNA from the patient and parents were subjected to direct sequencing for the COL7A1 gene. Two heterozygous mutations were detected in the affected child; one novel mutation designated c.4232delC in exon 38 and a single-base substitution (c.6573+1G>C) in intron 81. Deletion of a single cytosine at codon 1411 within exon 38 had produced a frameshift mutation that created a stop codon at codon 1427 (p.Pro1411Leufs*17). This intronic base substitution had led to aberrant splicing and a premature termination codon. This is a novel mutation of COL7A1 associated with DEB in a Korean patient, adding to the range of COL7A1 mutations related to DEB.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	1
Volume Number	12
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Date	2013-03-11
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Collagen Type Vii Genetics Epidermolysis Bullosa Dystrophica Mutation Codon, Terminator Dna Mutational Analysis Frameshift Mutation Genes, Recessive Infant Skin Metabolism Pathology Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article Case study

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