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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ma, H. L. Ge, X. Y. Cui, K. |
| Description | Country affiliation: China Author Affiliation: Cui K ( Department of Epidemiology and Biostatistics, School of Public Health, Liaoning Medical University, Jinzhou Liaoning, China.) |
| Abstract | Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease; increasing evidence indicates that the TNF- polymorphism is associated with progression of this disease. Few studies have focused upon association between TNF- -238G/A or -863C/A polymorphism and COPD risk. Reported associations have been controversial because of small sample size and varied study design among the different studies. We performed a meta-analysis to assess the correlation of these two polymorphisms in the TNF- gene with COPD risk. A comprehensive search was conducted to identify all published articles on the association between TNF- -238G/A or -863C/A polymorphism and COPD risk from different databases. Pooled odds ratios (ORs) with 95% confidence intervals (CI) were calculated, and the heterogeneity and publication bias were assessed. Eight articles with 10 eligible studies met our inclusion criteria; six studies were of the -238G/A polymorphism and the others involved the -863C/A polymorphism. In the case of the -863C/A polymorphism, significant association was detected only in Asians in the A allele carriers (GA+AA versus GG genotype) and allele (A versus G allele) model (OR = 0.505, 95%CI = 0.321-0.795 and OR = 0.560, 95%CI = 0.368-0.851, respectively). However, no significant association was detected for the -238G/A polymorphism. No evidence of between-study heterogeneity and publication bias was detected. We suggest a potentially protective role of the A allele in the TNF- -863C/ A polymorphism against developing COPD in Asians. This hypothesis needs further studies for confirmation. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 12 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2013-10-24 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Alleles Genetic Predisposition To Disease Polymorphism, Single Nucleotide Pulmonary Disease, Chronic Obstructive Genetics Tumor Necrosis Factor-alpha Gene Frequency Genotype Odds Ratio Publication Bias Meta-analysis Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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