NDLI: Variation patterns in individual fish responses to chemical stress among estuaries, seasons and genders: the case of the European flounder (Platichthys flesus) in the Bay of Biscay.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chérel, Yan Evrard, Estérine Cachot, Jérôme Larcher, Thibaut Laroche, Jean Bony, Sylvie Pichereau, Vianney Devier, Marie Hélène Devaux, Alain Quiniou, Louis Budzinski, Hélène Gauthier, Olivier Riso, Ricardo
Spatial Coverage	France
Description	Country affiliation: France Author Affiliation: Laroche J ( Laboratoire des Sciences de l'Environnement Marin LEMAR, Institut Universitaire Européen de la Mer, Université Européenne de Bretagne, Université de Brest, UMR 6539 CNRS/UBO/IRD/Ifremer, 29280 Plouzané, France. jean.laroche@univ-brest.fr)
Abstract	The objective was to describe and model variation patterns in individual fish responses to contaminants among estuaries, season and gender. Two hundred twenty-seven adult European flounders were collected in two seasons (winter and summer) in four estuaries along the Bay of Biscay (South West France), focusing on a pristine system (the Ster), vs. three estuaries displaying contrasted levels of contaminants (the Vilaine, Loire and Gironde). Twenty-three variables were measured by fish, considering the load of contaminants (liver metals, liver and muscle persistent organic pollutants, muscle polycyclic aromatic hydrocarbons); the gene expression (Cyt C oxydase, ATPase, BHMT, Cyt P450 1A1, ferritin); the blood genotoxicity (Comet test); and liver histology (foci of cellular alteration-tumour, steatosis, inflammation, abnormal glycogen storage). Canonical redundancy analysis (RDA) was used to model these variables using gender, season and estuary of origin as explanatory variables. The results underlined the homogeneity of fish responses within the pristine site (Ster) and more important seasonal variability within the three contaminated systems. The complete model RDA was significant and explained 35 % of total variance. Estuary and season respectively explained 30 and 5 % of the total independent variation components, whilst gender was not a significant factor. The first axis of the RDA explains nearly 27 % of the total variance and mostly represents a gradient of contamination. The links between the load of contaminants, the expression of several genes and the biomarkers were analysed considering different levels of chemical stress and a possible multi-stress, particularly in the Vilaine estuary.
ISSN	09441344
Issue Number	2
Volume Number	20
e-ISSN	16147499
Journal	Environmental Science and Pollution Research
Language	English
Publisher	Springer
Publisher Date	2013-02-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Flounder Physiology Stress, Physiological Water Pollutants, Chemical Analysis Toxicity Adenosine Triphosphatases Genetics Animals Bays Biological Markers Comet Assay Cytochrome P-450 Cyp1a1 Electron Transport Complex Iv Environmental Monitoring Methods Estuaries Female France Gene Expression Regulation Drug Effects Glycogen Metabolism Liver Chemistry Pathology Male Muscles Mutagenicity Tests Polycyclic Hydrocarbons, Aromatic Seasons Water Pollution Journal Article Research Support, Non-u.s. Gov't Discipline Environmental Science Discipline Environmental Chemistry
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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