NDLI: Use of mechanistic data in the IARC evaluations of the carcinogenicity of polychlorinated biphenyls and related compounds.

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Use of mechanistic data in the IARC evaluations of the carcinogenicity of polychlorinated biphenyls and related compounds.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baan, Robert Straif, Kurt Benbrahim-Tallaa, Lamia El Ghissassi, Fatiha Grosse, Yann Lauby-Secretan, Béatrice Loomis, Dana Guha, Neela Bouvard, Véronique
Description	Country affiliation: France Author Affiliation: Lauby-Secretan B ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France. secretanb@iarc.fr.); Loomis D ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France.); Baan R ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France.); El Ghissassi F ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France.); Bouvard V ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France.); Benbrahim-Tallaa L ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France.); Guha N ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France.); Grosse Y ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France.); Straif K ( International Agency for Research on Cancer, Section of the IARC Monographs, 150, cours Albert Thomas, 69372, Lyon, Cedex 08, France.)
Abstract	The IARC Monographs are a series of scientific reviews that identify environmental factors that can increase the risk of cancer in humans. In its first part, the principles and procedures of the IARC Monographs evaluations are summarized. In a second part, we present the most recent IARC evaluation of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs), performed in February 2013: PCBs and dioxin-like PCBs were both classified into group 1 'carcinogens,' while PBBs were evaluated as 'probably carcinogenic to humans' (group 2A). Noteworthy is that the relative contributions of different PCB congeners to the carcinogenicity of PCB mixtures are not known. The use of mechanistic data for the classification into a higher category is discussed in the context of the history of the consecutive evaluations of several related polychlorinated compounds.
ISSN	09441344
Issue Number	3
Volume Number	23
e-ISSN	16147499
Journal	Environmental Science and Pollution Research
Language	English
Publisher	Springer
Publisher Date	2016-02-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Carcinogens Toxicity Neoplasms Etiology Polychlorinated Biphenyls Toxicology Organization & Administration Animals Chemistry Humans Standards Journal Article Review Discipline Environmental Science Discipline Environmental Chemistry
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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