NDLI: Ameliorative effect of flaxseed oil against thiacloprid-induced toxicity in rats: hematological, biochemical, and histopathological study.

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Ameliorative effect of flaxseed oil against thiacloprid-induced toxicity in rats: hematological, biochemical, and histopathological study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hendawi, Mohamed Y. Alam, Rasha T. M. Abdellatief, Suhair A.
Description	Country affiliation: Egypt Author Affiliation: Hendawi MY ( Department of Plant Protection, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Sharkia, Egypt.); Alam RT ( Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Sharkia, Egypt. rashaalam@ymail.com.); Abdellatief SA ( Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Sharkia, Egypt.)
Abstract	The present study was carried out to evaluate the hematological, biochemical, and histopathological changes due to thiacloprid toxicity, and the potential protective role of flaxseed oil in male Wistar albino rats. Subacute thiacloprid intoxication induced a significant increase in RBCs, Hb, PCV, and WBCs count, and bone marrow micronucleus (MN) formation. Moreover, there was a significant increase in serum biochemical parameters related to hepatic injury: alanine aminotransferase (ALT) and alkaline phosphatase (ALP). Serum total protein and albumin levels were significantly reduced. Thiacloprid increases tumor necrosis factor-alpha (TNF- ) and interleukine-2(IL-2). There was a significant decrease in glutathione-S-transferase, while the lipid peroxidation (MDA) and cytochrome P450 activity were significantly increased. Flaxseed oil coadministration partially retrieved the changes in all studied parameters. Thiacloprid induced histopathological liver damage, which was minimized as a result of flaxseed oil treatment. In general, it was concluded that, flaxseed oil able to protect against thiacloprid-induced hepatoxicity.
ISSN	09441344
Issue Number	12
Journal	Environmental Science and Pollution Research
Volume Number	23
e-ISSN	16147499
Language	English
Publisher	Springer
Publisher Date	2016-06-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Science Discipline Environmental Chemistry
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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