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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cowan, Lauren S. Crawford, Jack T. |
| Spatial Coverage | United States |
| Description | Country affiliation: United States Author Affiliation: Cowan LS ( Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.) |
| Abstract | As part of the National Tuberculosis and Genotyping Surveillance Network, isolates obtained from all new cases of tuberculosis occurring in seven geographically separate surveillance sites from 1996 through 2000 were genotyped. A total of 10883 isolates were fingerprinted by the IS6110-restriction fragment length polymorphism method, yielding 6128 distinct patterns. Low-copy isolates (those with six or fewer bands) were also spoligotyped. The distribution of specific genotype clusters was examined. Databases were also examined for families of related genotypes. Analysis of IS6110 patterns showed 497 patterns related to the W-Beijing family; these patterns represent 946 (9%) of all isolates in the study. Six new sets of related fingerprint patterns were also proposed for isolates containing 6-15 copies of IS6110. These fingerprint sets contain up to 251 patterns and 414 isolates; together, they contain 21% of isolates in this copy number range. These sets of fingerprints may represent endemic strains distributed across the United States. |
| ISSN | 10806040 |
| e-ISSN | 10806059 |
| Journal | Emerging Infectious Diseases |
| Issue Number | 11 |
| Volume Number | 8 |
| Language | English |
| Publisher | Centers for Disease Control and Prevention |
| Publisher Date | 2002-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Mycobacterium Tuberculosis Genetics Isolation & Purification Sentinel Surveillance Tuberculosis Epidemiology Microbiology Dna Fingerprinting Databases, Factual Genotype Classification Polymorphism, Restriction Fragment Length Research Support, Non-u.s. Gov't Discipline Infectious Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Epidemiology Microbiology (medical) |
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