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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dambrosi, Alicia Ambroggi, Martha Abbate, Eduardo Vescovo, Marisa Capone, Lilian Ritacco, Viviana Marcela, Natiello Barrera, Lucía Isola, Nélida Di Lonardo, Martha Palmero, Domingo Poggi, Susana |
| Spatial Coverage | Argentina |
| Description | Country affiliation: Argentina Author Affiliation: Palmero D ( Hospital F. J. Muñiz, Buenos Aires, Argentina. djpalmero@intramed.net.ar) |
| Abstract | Initial multidrug-resistant (MDR) tuberculosis (TB) in HIV-negative patients treated at a Buenos Aires referral hospital from 1991 to 2000 was examined by using molecular clustering of available isolates. Of 291 HIV-negative MDRTB patients, 79 were initially MDR. We observed an ascending trend of initial MDRTB during this decade (p=0.0033). The M strain, which was responsible for an institutional AIDS-associated outbreak that peaked in 1995 to 1997, caused 24 of the 49 initial MDRTB cases available for restriction fragment length polymorphism. Of those, 21 were diagnosed in 1997 or later. Hospital exposure increased the risk of acquiring M strain-associated MDRTB by approximately two and a half times. The emergence of initial MDRTB among HIV-negative patients after 1997 was apparently a sequel of the AIDS-related outbreak. Because the prevalence of M strain-associated disease in the study population did not level out by the end of the decade, further expansion of this disease is possible. |
| ISSN | 10806040 |
| e-ISSN | 10806059 |
| Journal | Emerging Infectious Diseases |
| Issue Number | 8 |
| Volume Number | 9 |
| Language | English |
| Publisher | Centers for Disease Control and Prevention |
| Publisher Date | 2003-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Disease Outbreaks Hiv Seronegativity Mycobacterium Tuberculosis Drug Effects Tuberculosis, Multidrug-resistant Epidemiology Dna Fingerprinting Genetics Isolation & Purification Polymorphism, Restriction Fragment Length Research Support, Non-u.s. Gov't Discipline Infectious Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Epidemiology Microbiology (medical) |
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