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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mhaisalkar, S. G. Liedberg, B. Palaniappan, Al Moochhala, S. M. Wijaya, I. P. M. Goh, W. H. Tey, J. N. |
| Description | Country affiliation: Singapore Author Affiliation: Palaniappan A ( School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore. alps@ntu.edu.sg) |
| Abstract | A facile and high performance biosensing platform using aligned carbon nanotubes on quartz substrate is reported in this communication. Single walled carbon nanotubes are grown on quartz substrates by a chemical vapor deposition process and are characterized with field emission scanning electron microscopy and atomic force microscopy in order to verify the quality of the material. The quartz substrate is then directly used as a biosensor in a field effect transistor configuration. In order to demonstrate the sensing capabilities of the fabricated sensor devices, electronic detection of prostate specific antigen, a potential cancer biomarker, is carried out by adopting liquid gated configuration. A conductivity change due to the specific binding of target antigen with the immobilized receptor antibody demonstrates the sensing capabilities of the fabricated device. Sub-nM detection sensitivities have been obtained using the adopted direct immunoassay approach, which shows that the device responds to clinically relevant concentration regimes. |
| ISSN | 09565663 |
| Issue Number | 8 |
| Volume Number | 25 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-04-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Flow Injection Analysis Immunoassay Microfluidic Analytical Techniques Nanotubes, Carbon Chemistry Prostate-specific Antigen Analysis Quartz Equipment Design Equipment Failure Analysis Ultrastructure Reproducibility Of Results Sensitivity And Specificity Transistors, Electronic Evaluation Studies Journal Article Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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