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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Henihan, Grace Giraud, Gerard Mount, Andrew R. Corrigan, Damion K. Schulze, Holger Ghazal, Peter Pethig, Ronald Bachmann, Till T. Terry, Jonathan G. Ciani, Ilenia Campbell, Colin J. Walton, Anthony J. Crain, Jason |
| Description | Country affiliation: United kingdom Author Affiliation: Ciani I ( School of Chemistry & EaStCHEM, The University of Edinburgh, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK.) |
| Abstract | A method for label-free, electrochemical impedance immunosensing for the detection and quantification of three infection biomarkers in both buffer and directly in the defined model matrix of mock wound fluid is demonstrated. Triggering Receptor-1 Expressed on Myeloid cells (TREM-1) and Matrix MetalloPeptidase 9 (MMP-9) are detected via direct assay and N-3-oxo-dodecanoyl-l-HomoSerineLactone (HSL), relevant in bacterial quorum sensing, is detected using a competition assay. Detection is performed with gold screen-printed electrodes modified with a specific thiolated antibody. Detection is achieved in less than 1h straight from mock wound fluid without any extensive sample preparation steps. The limits of detection of 3.3 pM for TREM-1, 1.1 nM for MMP-9 and 1.4 nM for HSL are either near or below the threshold required to indicate infection. A relatively large dynamic range for sensor response is also found, consistent with interaction between neighbouring antibody-antigen complexes in the close-packed surface layer. Together, these three novel electrochemical immunosensors demonstrate viable multi-parameter sensing with the required sensitivity for rapid wound infection detection directly from a clinically relevant specimen. |
| ISSN | 09565663 |
| Issue Number | 1 |
| Volume Number | 31 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-01-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biological Markers Analysis Biosensing Techniques Instrumentation Conductometry Cytokines Dielectric Spectroscopy Immunoassay Wound Infection Immunology Animals Equipment Design Equipment Failure Analysis Humans Point-of-care Systems Reproducibility Of Results Sensitivity And Specificity Diagnosis Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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