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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Penmatsa, Varun Beidaghi, Majid Kawarada, Hiroshi Ruslinda, A. Rahim Wang, Chunlei |
| Description | Country affiliation: United States Author Affiliation: Penmatsa V ( Department of Mechanical and Materials Engineering, Florida International University, United States.) |
| Abstract | The potential of aptamers as ligand binding molecule has opened new avenues in the development of biosensors for cancer oncoproteins. In this paper, a label-free detection strategy using signaling aptamer/protein binding complex for platelet-derived growth factor (PDGF-BB) oncoprotein detection is reported. The detection mechanism is based on the release of fluorophore (TOTO intercalating dye) from the target binding aptamer's stem structure when it captures PDGF. Amino-terminated three-dimensional carbon microarrays fabricated by pyrolyzing patterned photoresist were used as a detection platform. The sensor showed near linear relationship between the relative fluorescence difference and protein concentration even in the sub-nanomolar range with an excellent detection limit of 5pmol. This detection strategy is promising in a wide range of applications in the detection of cancer biomarkers and other proteins. |
| ISSN | 09565663 |
| Issue Number | 1 |
| Volume Number | 39 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-01-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Aptamers, Nucleotide Chemistry Carbon Protein Array Analysis Instrumentation Proto-oncogene Proteins C-sis Analysis Biosensing Techniques Equipment Design Humans Limit Of Detection Evaluation Studies Journal Article Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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