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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Yan Liu, Fei Cao, Jing Feng, Chao Wang, Shouyu |
| Description | Author Affiliation: Cao J ( Single Molecule Nanometry Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China. Electronic address: http://www.feiliugroup.com.); Feng C ( Department of Pathology, The First People׳s Hospital of Shangqiu, Henan, Shangqiu 476000, China.); Liu Y ( Clinical Laboratory, The First People׳s Hospital of Shangqiu, Henan, Shangqiu 476000, China.); Wang S ( Department of Information Physics and Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.); Liu F ( Single Molecule Nanometry Laboratory, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China. Electronic address: feiliu24@njau.edu.cn.) |
| Abstract | Since many diseases are caused by pathogenic bacterial infections, accurate and rapid detection of pathogenic bacteria is in urgent need to timely apply appropriate treatments and to reduce economic costs. To end this, we designed molecular beacon-Au nanoparticle hybrid nanoprobes to improve the bacterial detection efficiency and sensitivity. Here, we show that the designed molecular beacon modified Au nanoparticles could specifically recognize synthetic DNAs targets and can readily detect targets in clinical samples. Moreover, the hybrid nanoprobes can recognize Escherichia coli within an hour at a concentration of 10(2) cfu/ml, which is 1000-folds sensitive than using molecular beacon directly. Our results show that the molecular beacon-Au nanoparticle hybrid nanoprobes have great potential in medical and biological applications. |
| ISSN | 09565663 |
| Volume Number | 57 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-07-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Methods Dna Probes Chemistry Escherichia Coli Infections Urine Escherichia Coli Isolation & Purification Gold Nanoparticles Economics Diagnosis Humans Limit Of Detection Ultrastructure Sensitivity And Specificity Evaluation Studies Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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