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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mozumder, Md Salatul Islam Garcia-Gonzalez, Linsey De Wever, Heleen Volcke, Eveline I. P. |
| Description | Author Affiliation: Mozumder MS ( Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology, Boeretang 200, 2400 Mol, Belgium); Garcia-Gonzalez L ( Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology, Boeretang 200, 2400 Mol, Belgium.); De Wever H ( Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology, Boeretang 200, 2400 Mol, Belgium.); Volcke EI ( Ghent University, Department of Biosystems Engineering, Coupure Links 653, 9000 Gent, Belgium.) |
| Abstract | This study evaluates the effect of sodium (Na(+)) concentration on the growth and PHB production by Cupriavidus necator. Both biomass growth and PHB production were inhibited by Na(+): biomass growth became zero at 8.9 g/L Na(+) concentration while PHB production was completely stopped at 10.5 g/L Na(+). A mathematical model for pure culture heterotrophic PHB production was set up to describe the Na(+) inhibition effect. The parameters related to Na(+) inhibition were estimated based on shake flask experiments. The accumulated Na(+) showed non-linear inhibition effect on biomass growth but linear inhibition effect on PHB production kinetics. Fed-batch experiments revealed that a high accumulation of Na(+) due to a prolonged growth phase, using NaOH for pH control, decreased the subsequent PHB production. The model was validated based on independent experimental data sets, showing a good agreement between experimental data and simulation results. |
| ISSN | 09608524 |
| Journal | Bioresource Technology |
| Volume Number | 191 |
| e-ISSN | 18732976 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cupriavidus Necator Metabolism Hydroxybutyrates Sodium Calibration Models, Biological Journal Article Validation Studies Discipline Bioresource |
| Content Type | Text |
| Resource Type | Article |
| Subject | Waste Management and Disposal Medicine Environmental Engineering Renewable Energy, Sustainability and the Environment Bioengineering |
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