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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Komoriya, A. Friesel, R. Maciag, T. |
| Abstract | Endothelial cell growth factor (ECGF) is a potent polypeptide mitogen for endothelial cells and fibroblasts. The mitogenic effects of ECGF are inhibited by the lymphokine gamma-interferon (gamma-IFN) in a dose- dependent manner. Gamma-IFN also induces a unique change in endothelial cell morphology which is maximally expressed in the presence of ECGF. The antiproliferative and phenotypic modulatory effects of gamma-IFN on endothelial cells are reversible. Inhibition of ECGF-induced endothelial cell proliferation by gamma-IFN is accompanied by a concentration- and time-dependent decrease in binding of 125I-ECGF to the endothelial cell surface. Scatchard analyses of the binding data in the presence and absence of gamma-IFN demonstrate a decrease in the number of ECGF-binding sites rather than a decrease in ligand affinity for the receptor. Cross-linking experiments with disuccinimidyl suberate demonstrate a decrease in the 170,000 Mr cross-linked receptor- ligand complex. These data suggest that gamma-IFN inhibits endothelial cell proliferation by a mechanism which involves growth factor receptor modulation. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 104 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1987-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Endothelium Cytology Growth Substances Pharmacology Interferon-gamma Physiology Cell Division Drug Effects Cells, Cultured Endothelial Growth Factors Metabolism Kinetics Receptors, Mitogen Receptors, Vascular Endothelial Growth Factor Recombinant Proteins Umbilical Veins Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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