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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Redelmeier, T. E. Meyerowitz, E. M. Tisdale, E. J. Schmid, S. L. Damke, H. Van Der Bliek, A. M. |
| Description | Author Affiliation: van der Bliek AM ( Division of Biology, California Institute of Technology, Pasadena 91125.) |
| Abstract | The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to block endocytosis at a stage after the initiation of coat assembly and preceding the sequestration of ligands into deeply invaginated coated pits. Membrane transport from the ER to the Golgi complex was unaffected indicating that dynamin mutants specifically block early events in endocytosis. These results demonstrate that mutations in the GTP-binding domain of dynamin block Tfn-endocytosis in mammalian cells and suggest that a functional dynamin GTPase is required for receptor-mediated endocytosis via clathrin-coated pits. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 122 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1993-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Ca(2+) Mg(2+)-ATPase Physiology Endocytosis Endosomes Metabolism Transferrin Alternative Splicing Amino Acid Sequence Chemistry Genetics Dynamins Endoplasmic Reticulum Ultrastructure Fluorescent Antibody Technique Golgi Apparatus HeLa Cells Molecular Sequence Data Mutation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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