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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hollinshead, M. Vaux, D. Fricker, M. White, N. |
| Description | Author Affiliation: Fricker M ( Department of Plant Sciences, Oxford, United Kingdom.) |
| Abstract | The nuclear envelope consists of a double-membraned extension of the rough endoplasmic reticulum. In this report we describe long, dynamic tubular channels, derived from the nuclear envelope, that extend deep into the nucleoplasm. These channels show cell-type specific morphologies ranging from single short stubs to multiple, complex, branched structures. Some channels transect the nucleus entirely, opening at two separate points on the nuclear surface, while others terminate at or close to nucleoli. These channels are distinct from other topological features of the nuclear envelope, such as lobes or folds. The channel wall consists of two membranes continuous with the nuclear envelope, studded with features indistinguishable from nuclear pore complexes, and decorated on the nucleoplasmic surface with lamins. The enclosed core is continuous with the cytoplasm, and the lumenal space between the membranes contains soluble ER-resident proteins (protein disulphide isomerase and glucose-6-phosphatase). Nuclear channels are also found in live cells labeled with the lipophilic dye DiOC6. Time-lapse imaging of DiOC6-labeled cells shows that the channels undergo changes in morphology and spatial distribution within the interphase nucleus on a timescale of minutes. The presence of a cytoplasmic core and nuclear pore complexes in the channel walls suggests a possible role for these structures in nucleo-cytoplasmic transport. The clear association of a subset of these structures with nucleoli would also be consistent with such a transport role. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 136 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1997-02-10 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Nucleus Ultrastructure Nuclear Envelope 3T3 Cells Animals Binding Sites CHO Cells Cell Line Cell Nucleolus Cercopithecus Aethiops Concanavalin A Metabolism Cricetinae HeLa Cells Interphase Mice Microscopy, Electron Vero Cells Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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