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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Holaska, J. M. Welch, K. Paschal, B. M. Macara, I. G. Lindsay, M. E. |
| Description | Author Affiliation: Lindsay ME ( Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22098, USA. mel3f@virginia.edu) |
| Abstract | Crm1 is a member of the karyopherin family of nucleocytoplasmic transport receptors and mediates the export of proteins from the nucleus by forming a ternary complex with cargo and Ran:GTP. This complex translocates through the nuclear pores and dissociates in the cytosol. The yeast protein Yrb2p participates in this pathway and binds Crm1, but its mechanism of action has not been established. We show that the human orthologue of Yrb2p, Ran-binding protein 3 (RanBP3), acts as a cofactor for Crm1-mediated export in a permeabilized cell assay. RanBP3 binds directly to Crm1, and the complex posseses an enhanced affinity for both Ran:GTP and cargo. RanBP3 shuttles between the nucleus and the cytoplasm by a Crm1-dependent mechanism, and the Crm1–RanBP3-NES-Ran:GTP quarternary complex can associate with nucleoporins. We infer that this complex translocates through the nuclear pore to the cytoplasm where it is disassembled by RanBP1 and Ran GTPase–activating protein. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 7 |
| Volume Number | 153 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2001-06-25 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Active Transport, Cell Nucleus Physiology Carrier Proteins Metabolism Karyopherins Nuclear Proteins Nucleocytoplasmic Transport Proteins Receptors, Cytoplasmic And Nuclear Genetics Cell Nucleus Cytoplasm GTPase-Activating Proteins Guanosine Triphosphate Macromolecular Substances Nuclear Pore Protein Binding Protein Structure, Tertiary Saccharomyces Substrate Specificity Two-Hybrid System Techniques Ran GTP-Binding Protein Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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