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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tatchell, K. Neiman, A. M. Bloecher, A. Tachikawa, H. |
| Description | Author Affiliation: Tachikawa H ( Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.) |
| Abstract | Sporulation of Saccharomyces cerevisiae is a developmental process in which a single cell is converted into four haploid spores. GIP1, encoding a developmentally regulated protein phosphatase 1 interacting protein, is required for spore formation. Here we show that GIP1 and the protein phosphatase 1 encoded by GLC7 play essential roles in spore development. The gip1Δ mutant undergoes meiosis and prospore membrane formation normally, but is specifically defective in spore wall synthesis. We demonstrate that in wild-type cells, distinct layers of the spore wall are deposited in a specific temporal order, and that gip1Δ cells display a discrete arrest at the onset of spore wall deposition. Localization studies revealed that Gip1p and Glc7p colocalize with the septins in structures underlying the growing prospore membranes. Interestingly, in the gip1Δ mutant, not only is Glc7p localization altered, but septins are also delocalized. Similar phenotypes were observed in a glc7–136 mutant, which expresses a Glc7p defective in interacting with Gip1p. These results indicate that a Gip1p–Glc7p phosphatase complex is required for proper septin organization and initiation of spore wall formation during sporulation. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 155 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2001-11-26 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carrier Proteins Metabolism Cell Wall Fungal Proteins Phosphoprotein Phosphatases Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Physiology Spores, Fungal Genetics Chemistry Meiosis Microscopy, Fluorescence Protein Phosphatase 1 Recombinant Fusion Proteins Ultrastructure Signal Transduction Time Factors Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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