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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Grosheva, I. Hüttelmaier, S. Illenberger, S. Rüdiger, M. Jockusch, B. M. Singer, R. H. |
| Description | Author Affiliation: Hüttelmaier S ( Cell Biology, Zoological Institute, Technical University of Braunschweig, D-38092 Braunschweig, Germany.) |
| Abstract | By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein termed raver1. Raver1 is an 80-kD multidomain protein and widely expressed but to varying amounts in different cell lines. In situ and in vitro, raver1 forms complexes with the microfilament-associated proteins vinculin, metavinculin, and α-actinin and colocalizes with vinculin/metavinculin and α-actinin at microfilament attachment sites, such as cell–cell and cell matrix contacts of epithelial cells and fibroblasts, respectively, and in costameres of skeletal muscle. The $NH_{2}-terminal$ part of raver1 contains three RNA recognition motifs with homology to members of the heterogeneous nuclear RNP (hnRNP) family. Raver1 colocalizes with polypyrimidine tract binding protein (PTB)/hnRNPI, a protein involved in RNA splicing of microfilament proteins, in the perinucleolar compartment and forms complexes with PTB/hnRNPI. Hence, raver1 is a dual compartment protein, which is consistent with the presence of nuclear location signal and nuclear export sequence motifs in its sequence. During muscle differentiation, raver1 migrates from the nucleus to the costamere. We propose that raver1 may coordinate RNA processing and targeting as required for microfilament anchoring in specific adhesion sites. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 155 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2001-11-26 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Actinin Metabolism Carrier Proteins Nuclear Proteins RNA-Binding Proteins Ribonucleoproteins Vinculin Actin Cytoskeleton Active Transport, Cell Nucleus Physiology Amino Acid Sequence Animals Chemistry Genetics Cell Line Epithelial Cells Fibroblasts Immunohistochemistry Intercellular Junctions Ligands Mice Molecular Sequence Data Muscle, Skeletal Cytology Polypyrimidine Tract-Binding Protein Protein Binding RNA, Messenger Recombinant Fusion Proteins Tissue Distribution Two-Hybrid System Techniques Analogs & Derivatives Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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