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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yagi, Takeshi Kabu, Koki Yamamoto, Tadashi Geha, Raif S. Tezuka, Tohru Nishizumi, Hirofumi Kitamura, Daisuke Yamasaki, Satoru Hattori, Kotaro Hirano, Toshio Nishida, Keigo Ito, Yukitaka Goitsuka, Ryo |
| Description | Author Affiliation: Nishida K ( Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Kanagawa 230-0045, Japan.) |
| Abstract | The aggregation of high affinity IgE receptors (Fcɛ receptor I [FcɛRI]) on mast cells is potent stimulus for the release of inflammatory and allergic mediators from cytoplasmic granules. However, the molecular mechanism of degranulation has not yet been established. It is still unclear how FcɛRI-mediated signal transduction ultimately regulates the reorganization of the cytoskeleton and how these events lead to degranulation. Here, we show that FcɛRI stimulation triggers the formation of microtubules in a manner independent of calcium. Drugs affecting microtubule dynamics effectively suppressed the FcɛRI-mediated translocation of granules to the plasma membrane and degranulation. Furthermore, the translocation of granules to the plasma membrane occurred in a calcium-independent manner, but the release of mediators and granule–plasma membrane fusion were completely dependent on calcium. Thus, the degranulation process can be dissected into two events: the calcium-independent microtubule-dependent translocation of granules to the plasma membrane and calcium-dependent membrane fusion and exocytosis. Finally, we show that the Fyn/Gab2/RhoA (but not Lyn/SLP-76) signaling pathway plays a critical role in the calcium-independent microtubule-dependent pathway. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 1 |
| Volume Number | 170 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2005-07-04 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Membrane Immunology Mast Cells Secretion Microtubules Metabolism Receptors, IgE Secretory Vesicles Animals Calcium Calcium Signaling Drug Effects Cell Degranulation Physiology Cells, Cultured Exocytosis Inflammation Mediators Cytology Membrane Fusion Mice Mice, Inbred C57BL Phosphoproteins Protein Transport Proto-Oncogene Proteins Proto-Oncogene Proteins C-fyn Receptor Aggregation Signal Transduction RhoA GTP-Binding Protein Src-Family Kinases Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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